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Insomnia in central neurologic diseases--occurrence and management.

Sleep medicine reviews
December 1, 2011
Geert Mayer et al. (4 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the role of melatonin in stabilizing the sleep-wake circadian rhythm and reducing sleep latency in patients with dementia and Parkinson's disease.

Results Summary

Melatonin was found to stabilize the sleep-wake circadian rhythm and shorten sleep latency in patients with dementia and Parkinson's disease, suggesting potential benefits for insomnia management in these populations.

Population

Patients with dementia and Parkinson's disease.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (7)
InterventionDirectionEndpointPopulationDosageImpactClaim #
hypnotics
decrease
insomnia
most disorders
short term
may be recommended
#1
sedating antidepressants
decrease
insomnia
stroke and Parkinson's disease (PD) patients
-
may be an effective treatment
#2
melatonin
increase
sleep-wake circadian rhythm
dementias and PD
-
can stabilize
#3
light treatment
increase
sleep-wake circadian rhythm
dementias and PD
-
can stabilize
#4
melatonin
decrease
sleep latency
dementias and PD
-
can shorten
#5
light treatment
decrease
sleep latency
dementias and PD
-
can shorten
#6
cognitive behavioral therapy (CBT)
decrease
insomnia symptoms
most of the central neurological diseases
-
can be effective in treating
#7
Abstract

The objective of this review is to highlight the impact of insomnia in central neurological disorders by providing information on its prevalence and give recommendations for diagnosis and treatment. Insomnia in neurological disorders is a frequent, but underestimated symptom. Its occurrence may be a direct consequence of the disease itself or may be secondary to pain, depression, other sleep disorders or the effects of medications. Insomnia can have a significant impact on the patient's cognitive and physical function and may be associated with psychological distress and depression. Diagnosis of insomnia is primarily based on medical history and validated questionnaires. Actigraphy is a helpful diagnostic tool for assessing the circadian sleep-wake rhythm. For differential diagnosis and to measure the duration of sleep full polysomnography may be recommended. Prior to initiating treatment the cause of insomnia must be clearly identified. First line treatment aims at the underlying neurologic disease. The few high quality treatment studies show that short term treatment with hypnotics may be recommended in most disorders after having ruled out high risk for adverse effects. Sedating antidepressants may be an effective treatment for insomnia in stroke and Parkinson's disease (PD) patients. Melatonin and light treatment can stabilize the sleep-wake circadian rhythm and shorten sleep latency in dementias and PD. Cognitive behavioral therapy (CBT) can be effective in treating insomnia symptoms associated with most of the central neurological diseases. The prevalence and treatment of insomnia in neurological diseases still need to be studied in larger patient groups with randomized clinical trials to a) better understand their impact and causal relationship and b) to develop and improve specific evidence-based treatment strategies.

Medical Subject Headings (MeSH)
Brain InjuriesCentral Nervous System DiseasesDementiaEpilepsyHeadacheHumansHypnotics and SedativesParkinson DiseaseSleep Initiation and Maintenance DisordersStroke
Study Links
Quality Scores
SafetyNot Assessed
Efficacy75/10
Quality65/10
Citation Metrics
Total Citations70
Citations/Year5.0
Relative Citation Ratio2.48
NIH Percentile80.5%
Research Impact Scores
APT Score0.95
Weight Score1.29
Normalized Score0.63
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Insomnia in central neurologic diseases--occurrence and mana... | Panacea Index