Influence of soy lecithin administration on hypercholesterolemia.
Study Goal
The researchers aimed to determine whether soy lecithin administration could reduce cholesterol concentrations in hypercholesterolemic patients by increasing biliary secretion.
Results Summary
The study found significant reductions in total cholesterol (40.66% and 42.00%) and LDL cholesterol (42.05% and 56.15%) after one and two months of soy lecithin administration, suggesting its potential as a supplemental treatment for hypercholesterolemia.
Population
Hypercholesterolemic patients
Effective Dosage
500 mg daily (one capsule)
Duration
Two months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
lecithin-rich diet | neutral | cholesterol homeostasis and hepatic lipoprotein metabolism | - | - | can modify | #1 |
lecithin administration | decrease | cholesterol concentrations | hypercholesterolemic patients | - | may reduce | #2 |
lecithin administration | increase | biliary secretion | hypercholesterolemic patients | - | by increasing | #3 |
soy lecithin administration | decrease | total cholesterol | hypercholesterolemic patients | 40.66% | showed a reduction of | #4 |
soy lecithin administration | decrease | total cholesterol | hypercholesterolemic patients | 42.00% | showed a reduction of | #5 |
soy lecithin administration | decrease | LDL cholesterol | hypercholesterolemic patients | 42.05% | showed a reduction of | #6 |
soy lecithin administration | decrease | LDL cholesterol | hypercholesterolemic patients | 56.15% | showed a reduction of | #7 |
soy lecithin administration | decrease | total cholesterol and LDL-cholesterol concentrations | - | - | A significant reduction in | #8 |
administration of soy lecithin daily | neutral | a supplemental treatment in hypercholesterolemia | - | - | may be used as | #9 |
Recent studies suggest that lecithin-rich diet can modify cholesterol homeostasis and hepatic lipoprotein metabolism. Considering the phytotherapeutic impact of lecithin, this work hypothesizes that lecithin administration in hypercholesterolemic patients may reduce cholesterol concentrations by increasing biliary secretion. Total cholesterol and LDL were evaluated after soy lecithin administration in hypercholesterolemic patients. One soy lecithin capsule (500 mg/RP-Sherer) was administrated daily. One-two months before the treatment beginning, blood samples were collected for total lipids and cholesterol fractions analysis. The results showed a reduction of 40.66% and 42.00% in total cholesterol and of 42.05% and 56.15% in LDL cholesterol after treatment for one and two months, respectively. A significant reduction in total cholesterol and LDL-cholesterol concentrations was observed during the first month of treatment, suggesting that the administration of soy lecithin daily may be used as a supplemental treatment in hypercholesterolemia.