Reduced serum cholesterol with dietary change using fat-modified and oat bran supplemented diets.
Study Goal
The researchers aimed to determine the effectiveness of oat bran supplementation, alone or combined with a low-fat, low-cholesterol diet, in lowering blood lipids in hypercholesterolemic individuals.
Results Summary
All groups, including those with oat bran supplementation, experienced significant decreases in total serum cholesterol (10-17%) without significant differences between groups. High-density lipoprotein cholesterol decreased in most groups except one, and dietary intake of energy, fat, and cholesterol decreased across all groups.
Population
71 free-living men and women with hypercholesterolemia (serum cholesterol greater than the 75th percentile).
Effective Dosage
50 gm/day oat bran (LFLC + OB and OB groups) or 42.5 gm/day processed oat bran (POB group).
Duration
4-week intervals (exact total duration not specified in abstract).
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
low-fat, low-cholesterol diet | decrease | cholesterol | free-living men and women with hypercholesterolemia | null | experienced significant decreases | #1 |
low-fat, low-cholesterol diet plus 50 gm/day oat bran | decrease | cholesterol | free-living men and women with hypercholesterolemia | null | experienced significant decreases | #2 |
50 gm/day oat bran supplemented diet | decrease | cholesterol | free-living men and women with hypercholesterolemia | null | experienced significant decreases | #3 |
42.5 gm/day processed oat bran (ready-to-eat cereal containing beta-glucan concentrated from oat bran) | decrease | cholesterol | free-living men and women with hypercholesterolemia | null | experienced significant decreases | #4 |
low-fat, low-cholesterol diet | decrease | total serum cholesterol | free-living men and women with hypercholesterolemia | 10% to 17% | average decrease | #5 |
low-fat, low-cholesterol diet plus 50 gm/day oat bran | decrease | total serum cholesterol | free-living men and women with hypercholesterolemia | 10% to 17% | average decrease | #6 |
50 gm/day oat bran supplemented diet | decrease | total serum cholesterol | free-living men and women with hypercholesterolemia | 10% to 17% | average decrease | #7 |
42.5 gm/day processed oat bran (ready-to-eat cereal containing beta-glucan concentrated from oat bran) | decrease | total serum cholesterol | free-living men and women with hypercholesterolemia | 10% to 17% | average decrease | #8 |
low-fat, low-cholesterol diet | decrease | high-density lipoprotein cholesterol concentrations | free-living men and women with hypercholesterolemia | null | decreased | #9 |
low-fat, low-cholesterol diet plus 50 gm/day oat bran | decrease | high-density lipoprotein cholesterol concentrations | free-living men and women with hypercholesterolemia | null | decreased | #10 |
50 gm/day oat bran supplemented diet | decrease | high-density lipoprotein cholesterol concentrations | free-living men and women with hypercholesterolemia | null | decreased | #11 |
42.5 gm/day processed oat bran (ready-to-eat cereal containing beta-glucan concentrated from oat bran) | increase | high-density lipoprotein cholesterol concentrations | free-living men and women with hypercholesterolemia | null | slight increase | #12 |
low-fat, low-cholesterol diet | decrease | energy, fat, and cholesterol intakes | free-living men and women with hypercholesterolemia | null | decreased | #13 |
low-fat, low-cholesterol diet plus 50 gm/day oat bran | decrease | energy, fat, and cholesterol intakes | free-living men and women with hypercholesterolemia | null | decreased | #14 |
50 gm/day oat bran supplemented diet | decrease | energy, fat, and cholesterol intakes | free-living men and women with hypercholesterolemia | null | decreased | #15 |
42.5 gm/day processed oat bran (ready-to-eat cereal containing beta-glucan concentrated from oat bran) | decrease | energy, fat, and cholesterol intakes | free-living men and women with hypercholesterolemia | null | decreased | #16 |
low-fat, low-cholesterol diet | decrease | intakes of calcium, copper, folic acid, and potassium | free-living men and women with hypercholesterolemia | null | reduced | #17 |
low-fat, low-cholesterol diet plus 50 gm/day oat bran | decrease | intakes of calcium, copper, folic acid, and potassium | free-living men and women with hypercholesterolemia | null | reduced | #18 |
50 gm/day oat bran supplemented diet | decrease | intakes of calcium, copper, folic acid, and potassium | free-living men and women with hypercholesterolemia | null | reduced | #19 |
42.5 gm/day processed oat bran (ready-to-eat cereal containing beta-glucan concentrated from oat bran) | decrease | intakes of calcium, copper, folic acid, and potassium | free-living men and women with hypercholesterolemia | null | reduced | #20 |
A low-fat, low-cholesterol diet and oat bran supplementation for treatment of hypercholesterolemia were studied for their effectiveness in lowering blood lipids and their impact on dietary intake. Seventy-one free-living men and women with hypercholesterolemia (serum cholesterol greater than 75th percentile) were randomly assigned to one of the following four groups: low-fat, low-cholesterol diet (LFLC); low-fat, low-cholesterol diet plus 50 gm/day oat bran (LFLC + OB); 50 gm/day oat bran supplemented diet (OB); or 42.5 gm/day processed oat bran (ready-to-eat cereal containing beta-glucan concentrated from oat bran) (POB). Subjects assigned to regimens OB and POB were requested to add the oat supplement without making additional changes in their diet. Serum cholesterol and high-density lipoprotein cholesterol analyses were performed at 4-week intervals, and diet records were assigned and analyzed. All groups experienced significant decreases in cholesterol from original levels (p less than .05). The average decrease in total serum cholesterol varied from 10% to 17%, with no significant differences among the four groups. High-density lipoprotein cholesterol concentrations decreased in all groups except group 4, in which there was a slight increase; however, no differences were found between groups. Energy, fat, and cholesterol intakes decreased in all groups, suggesting that displacement of higher fat foods from the diet may be one of the many mechanisms whereby oat supplements lower serum cholesterol. In addition, all groups reduced their intakes of calcium, copper, folic acid, and potassium from marginal levels at the beginning of the study.(ABSTRACT TRUNCATED AT 250 WORDS)