Change of BMD after weaning or resumption of menstruation in Chinese women with different FokI VDR-genotypes: a randomized, placebo-controlled, calcium supplementation trial.
Study Goal
To investigate the effect of calcium supplementation on bone mineral density (BMD) in Chinese women with different FokI vitamin D receptor (VDR) genotypes after weaning or resumption of menstruation during lactation.
Results Summary
Calcium supplementation (600 mg daily) significantly increased BMD at the lumbar spine and left hip in women, with the greatest improvement observed in those with the FF VDR genotype. Women with the FF genotype regained more BMD compared to those with the ff genotype.
Population
Chinese women with different FokI VDR genotypes (FF, Ff, ff) after weaning or resumption of menstruation during lactation.
Effective Dosage
600 mg once daily as CaCO3
Duration
1 year
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
calcium supplementation (600 mg once daily as CaCO3) | increase | BMD at lumbar spine | Chinese women after weaning or resumption of menstruation during lactation | - | increased significantly | #1 |
calcium supplementation (600 mg once daily as CaCO3) | increase | BMD at left hip | Chinese women after weaning or resumption of menstruation during lactation | - | increased significantly | #2 |
calcium supplementation (600 mg once daily as CaCO3) | increase | BMD at lumbar spine and at left hip | Chinese women after weaning or resumption of menstruation during lactation with different FokI VDR genotypes (FF, Ff, and ff) | - | increased with a trend among different FokI VDR genotypes such as FF > Ff > ff | #3 |
calcium supplementation (600 mg once daily as CaCO3) | increase | BMD at lumbar spine | Chinese women after weaning or resumption of menstruation during lactation with FF VDR genotype | - | increased much more rapidly | #4 |
calcium supplementation (600 mg once daily as CaCO3) | increase | BMD | Chinese women after weaning or resumption of menstruation during lactation with FF VDR genotype | - | regained more BMD | #5 |
Daily calcium 600 mg supplementation | increase | bone health | women with FF VDR genotype | - | has beneficial effect | #6 |
OBJECTIVE: To investigate the effect of calcium supplementation on bone mineral density (BMD) in Chinese women with different FokI vitamin D receptor (VDR) genotypes (FF, Ff, and ff) after weaning or resumption of menstruation during lactation. METHODS: A total of 40 subjects with the same FokI VDR genotype were randomly divided into two groups: one received calcium tablet (600 mg once daily as CaCO(3)) and the other placebo tablet once daily for 1 year. At baseline, BMD was measured by dual-energy X-ray absorptiometry at lumbar spine (L2-L4) and at left hip whereas serum PICP, serum OC, and urinary CTX, serum 25(OH)VitD(3), and serum estradiol were measured at weaning and 1 year thereafter. RESULTS: After the intervention, BMD at lumbar spine and at left hip increased significantly in all these women with a trend among different FokI VDR genotypes such as FF > Ff > ff (P<0.05, <0.01, and <0.001, respectively). BMD at lumbar spine in women with FF VDR genotype increased much more rapidly than in those with ff VDR genotype (P<0.05). Compared with the control group women with the FF genotype regained more BMD after calcium supplementation (P<0.05). CONCLUSION: Daily calcium 600 mg supplementation has beneficial effect on the bone health of women with FF VDR genotype.