Lipid-lowering effect of Rhus coriaria L. (sumac) fruit extract in hypercholesterolemic rats.
Study Goal
The researchers aimed to investigate the hypolipidemic and protective effects of sumac fruit extract in high cholesterol diet-fed rats.
Results Summary
Sumac fruit extract significantly reduced elevated cholesterol and triglyceride levels, reversed hypertrophic cardiac histology, and showed no acute toxicity in rats. The extract demonstrated cardioprotective and hepatoprotective effects in hypercholesterolemic conditions.
Population
Male Wistar rats fed a high cholesterol diet.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
high cholesterol diet (HCD) | increase | levels of total cholesterol (TC) | rats | p < 0.001 | significant (p < 0.001) increase | #1 |
high cholesterol diet (HCD) | increase | levels of triglycerides (TG) | rats | p < 0.001 | significant (p < 0.001) increase | #2 |
high cholesterol diet (HCD) | increase | serum aspartate aminotransferase | rats | - | augmented activities | #3 |
high cholesterol diet (HCD) | increase | alanine aminotransferase | rats | - | augmented activities | #4 |
high cholesterol diet (HCD) | increase | lactate dehydrogenase | rats | - | augmented activities | #5 |
aqueous methanol extract of sumac fruits | decrease | the above alterations observed in hypercholesterolemic rats | hypercholesterolemic rats | - | reduced | #6 |
sumac extract | decrease | hypertrophic cardiac histology | HCD fed rats | - | reversed | #7 |
aqueous methanol extract of sumac fruits | no change | acute toxicity | male Wistar rats | - | showed no evidence of acute toxicity | #8 |
sumac fruit extract | decrease | lipid abnormalities | HCD fed rats | - | minimized | #9 |
sumac fruit extract | decrease | abnormal biochemical changes | HCD fed rats | - | minimized | #10 |
sumac fruit extract | neutral | cardioprotective activities | hypercholesterolemic condition | - | possesses | #11 |
sumac fruit extract | neutral | hepatoprotective activities | hypercholesterolemic condition | - | possesses | #12 |
Hyperlipidemia is a major risk factor for development of atherosclerosis. In the present study, the hypolipidemic effects of sumac (Rhus coriaria L.) fruits in high cholesterold diet (HCD)-fed rats was investigated. There was a significant (p < 0.001) increase in the levels of total cholesterol (TC) and triglycerides (TG) along with augmented activities of serum aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase. Treatment with aqueous methanol extract of sumac fruits reduced the above alterations observed in hypercholesterolemic rats. Sumac extract also reversed the hypertrophic cardiac histology. Furthermore, in vivo toxicological studies showed no evidence of acute toxicity of the extract in male Wistar rats. In conclusion, sumac fruit extract intervention minimized the lipid abnormalities and abnormal biochemical changes induced in HCD fed rats. This shows that sumac fruit extract possesses cardioprotective and hepatoprotective activities which will be beneficial in hypercholesterolemic condition.