The role of melatonin treatment in chronic kidney disease.
Study Goal
The researchers aimed to evaluate the therapeutic benefits of melatonin in addressing sleep disturbances, blood pressure alterations, and oxidative stress in patients with Chronic Kidney Disease (CKD).
Results Summary
The study found that melatonin treatment improved sleep disorders in CKD patients, had beneficial effects on blood pressure, and provided protection against oxidative stress and inflammation in renal disorders. Controlled trials supported these findings.
Population
Patients with Chronic Kidney Disease (CKD), particularly those on hemodialysis.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin treatment | decrease | sleep disorders related to chronic kidney disease | patients with Chronic Kidney Disease (CKD), especially those who are on hemodialysis | - | therapeutic benefit | #1 |
melatonin | decrease | blood pressure alterations | CKD states | - | beneficial effect | #2 |
melatonin | decrease | oxidative stress and inflammation | renal disorders | - | protection | #3 |
The pineal hormone melatonin plays a major role in circadian sleep-wake rhythm. Patients with Chronic Kidney Disease (CKD), especially those who are on hemodialysis, frequently suffer from sleep disturbances. In this review an overview is given of the classification of stages of chronic kidney disease, followed by a presentation of the circadian rhythm disorders in renal disease involving sleep disturbances in relation to melatonin deficiency. The therapeutic benefit of melatonin treatment in sleep disorders related to chronic kidney disease including the controlled trials solving this topic, is described. Furthermore, the beneficial effect of melatonin on blood pressure alterations in CKD states and the protection of melatonin in oxidative stress and inflammation in renal disorders are explored. Finally a hypothetic model is described for the relation between circadian rhythm disorders and CKD.