[Influence of combined lacto-vegetarian diet and selective beta-blocking agents on clinical and metabolic indices in patients with coronary heart disease].
Study Goal
The researchers aimed to compare the effects of a lacto-vegetarian diet versus a standard mixed diet on clinical, hemodynamic, and metabolic parameters in coronary heart disease patients treated with beta-blockers.
Results Summary
The vegetarian diet group showed more pronounced improvements in blood pressure, exercise tolerance, and lipid profiles (reduced total cholesterol, LDL cholesterol, and atherogenic coefficient, increased HDL cholesterol) compared to the standard diet group. The vegetarian diet also counteracted the hyperlipidemic effects of beta-blockers.
Population
42 patients with coronary heart disease post-myocardial infarction, treated with selective beta-adrenoblockers.
Effective Dosage
Not specified (dietary intervention only)
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
methoprolol (50 mg/daily) and antiatherogenic lacto vegetarian diet | increase | clinical and gemodynamic parameters | patients with coronary heart disease, after myocardial infarct | - | positive changes | #1 |
methoprolol (50 mg/daily) and standard mixed antiatherogenic diet | increase | clinical and gemodynamic parameters | patients with coronary heart disease, after myocardial infarct | - | positive changes | #2 |
methoprolol (50 mg/daily) and antiatherogenic lacto vegetarian diet | decrease | blood pressure | patients on vegetarian diet | - | more pronounced decrease | #3 |
methoprolol (50 mg/daily) and antiatherogenic lacto vegetarian diet | increase | exercise tolerance | patients on vegetarian diet | - | more significant increase | #4 |
methoprolol (50 mg/daily) and antiatherogenic lacto vegetarian diet | decrease | total cholesterol on the serum of blood | vegetarian group | 16% | decreased | #5 |
methoprolol (50 mg/daily) and antiatherogenic lacto vegetarian diet | decrease | low-density lipoproteins cholesterol | vegetarian group | 18% | decreased | #6 |
methoprolol (50 mg/daily) and antiatherogenic lacto vegetarian diet | decrease | atherogenic coefficient (KA) | vegetarian group | 31% | decreased | #7 |
methoprolol (50 mg/daily) and antiatherogenic lacto vegetarian diet | increase | high-density lipoprotein cholesterol | vegetarian group | 14% | increased | #8 |
methoprolol (50 mg/daily) and standard mixed antiatherogenic diet | decrease | high-density lipoprotein cholesterol | control group | - | decreased | #9 |
balanced antiatherogenic lacto vegetarian diet | decrease | hyperlipedemic effect caused by the selective beta-adrenoblockers | patients with coronary heart disease | - | prevents | #10 |
balanced antiatherogenic lacto vegetarian diet | decrease | negative effect on lipid metabolism | - | - | agent for preventing | #11 |
Clinical, hemodynamic and metabolic parameters were investigated for 42 patients with coronary heart disease, after myocardial infarct, recieved selective beta-adrenoblockers. Patients were divided in two groups. The first group (24 patients) were given methoprolol (50 mg/daily) and antiatherogenic lacto vegetarian diet, the second (18 patients)--methoprolol (50 mg/daily) and standard mixed antiatherogenic diet. After the treatment, positive changes clinical and gemodynamic parameters were observed in both groups of patients. Among the clinical symptoms, a more pronounced decrease in blood pressure in the patients on vegetarian diet and a more significant increase in their exercise tolerance. The level of total cholesterol on the serum of blood decreased by 16%, low-density lipoproteins cholesterol decreased by 18%, the atherogenic coefficient (KA) decreased by 31%, only in vegetarian group. High-density lipoprotein cholesterol increased in vegetarian group, by 14% and decreased in control group. Balanced antiatherogenic lacto vegetarian diet in patients with coronary heart disease prevents the hyperlipedemic effect caused by the selective beta-adrenoblockers and it is an agent for preventing its negative effect on lipid metabolism.