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Management of common sleep disorders.

American family physician
January 1, 1970
Kannan Ramar et al. (2 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the role of melatonin in treating rapid eye movement sleep behavior disorder (RBD).

Results Summary

Melatonin was found to be an effective treatment option for RBD, alongside environmental safety measures and clonazepam, by reducing harmful dream enactment behaviors.

Population

Patients with rapid eye movement sleep behavior disorder.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (10)
InterventionDirectionEndpointPopulationDosageImpactClaim #
cognitive behavior therapy
decrease
insomnia
patients with insomnia
-
treated
#1
sleep hypnotics
decrease
insomnia
patients with insomnia
-
treated
#2
treatment based on symptom frequency
decrease
Restless legs syndrome
patients with Restless legs syndrome
-
treated
#3
stimulants, such as modafinil
decrease
Narcolepsy
patients with Narcolepsy
-
treated
#4
selective serotonin reuptake inhibitors
decrease
Narcolepsy
patients with Narcolepsy
-
treated
#5
gamma hydroxybutyric acid (sodium oxybate)
decrease
Narcolepsy
patients with Narcolepsy
-
treated
#6
Continuous positive airway pressure
decrease
obstructive sleep apnea
patients with obstructive sleep apnea
-
most common and effective treatment
#7
environmental safety measures
decrease
Rapid eye movement sleep behavior disorder
patients with Rapid eye movement sleep behavior disorder
-
treated
#8
melatonin
decrease
Rapid eye movement sleep behavior disorder
patients with Rapid eye movement sleep behavior disorder
-
treated
#9
clonazepam
decrease
Rapid eye movement sleep behavior disorder
patients with Rapid eye movement sleep behavior disorder
-
treated
#10
Abstract

Sleep disorders are common and affect sleep quality and quantity, leading to increased morbidity. Patients with sleep disorders can be categorized as those who cannot sleep, those who will not sleep, those with excessive daytime sleepiness, and those with increased movements during sleep. Insomnia, defined as difficulty initiating or maintaining sleep that results in daytime impairment, is diagnosed using history findings and treated with cognitive behavior therapy, with or without sleep hypnotics. Restless legs syndrome is characterized by an urge to move the legs that worsens with rest, is relieved by movement, and often occurs in the evening or at night. Restless legs syndrome is treated based on the frequency of symptoms. Narcolepsy is characterized by excessive sleepiness, cataplexy, hypnagogic or hypnopompic hallucinations, and sleep paralysis. It is diagnosed using a sleep log or actigraphy, followed by overnight polysomnography and a multiple sleep latency test. Narcolepsy is treated with stimulants, such as modafinil; selective serotonin reuptake inhibitors; or gamma hydroxybutyric acid (sodium oxybate). Patients with snoring and witnessed apneas may have obstructive sleep apnea, which is diagnosed using overnight polysomnography. Continuous positive airway pressure is the most common and effective treatment for obstructive sleep apnea. Rapid eye movement sleep behavior disorder is characterized by increased muscle tone during rapid eye movement sleep, resulting in the patient acting out dreams with possible harmful consequences. It is diagnosed based on history and polysomnography findings, and treated with environmental safety measures and melatonin or clonazepam.

Medical Subject Headings (MeSH)
ActigraphyCentral Nervous System StimulantsCognitive Behavioral TherapyContinuous Positive Airway PressureHumansHypnotics and SedativesNarcolepsyPolysomnographyPractice Guidelines as TopicREM Sleep Behavior DisorderRestless Legs SyndromeSleep Apnea, ObstructiveSleep Initiation and Maintenance DisordersSleep Wake Disorders
Study Links
PubMed ID23944726
Quality Scores
SafetyNot Assessed
Efficacy75/10
Quality60/10
Citation Metrics
Total Citations50
Citations/Year4.2
Relative Citation Ratio2.25
NIH Percentile78%
Research Impact Scores
APT Score0.75
Weight Score1.57
Normalized Score0.62
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