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Treatment of the sleep disorders associated with Parkinson's disease.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
January 1, 2014
Lynn Marie Trotti et al. (2 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to explore potential treatments, including light therapy, for insomnia in Parkinson's disease patients.

Results Summary

Preliminary evidence suggests light therapy might be beneficial for insomnia in Parkinson's disease, but optimal treatments are yet to be determined. The abstract does not provide detailed results specific to light therapy.

Population

Patients with Parkinson's disease experiencing sleep disorders, particularly insomnia.

Effective Dosage

Not available

Duration

Not available

Interactions

None mentioned

Extracted Claims (12)
InterventionDirectionEndpointPopulationDosageImpactClaim #
melatonin
neutral
rapid eye movement sleep behavior disorder
patients with Parkinson's disease
-
most commonly used
#1
clonazepam
neutral
rapid eye movement sleep behavior disorder
patients with Parkinson's disease
-
most commonly used
#2
rivastigmine
neutral
rapid eye movement sleep behavior disorder
patients whose behaviors are refractory to the former
-
might be a useful option
#3
cognitive-behavioral therapy
neutral
insomnia
patients with Parkinson's disease
-
might be beneficial
#4
light therapy
neutral
insomnia
patients with Parkinson's disease
-
might be beneficial
#5
eszopiclone
neutral
insomnia
patients with Parkinson's disease
-
might be beneficial
#6
donepezil
neutral
insomnia
patients with Parkinson's disease
-
might be beneficial
#7
melatonin
neutral
insomnia
patients with Parkinson's disease
-
might be beneficial
#8
modafinil
increase
subjective measures of excessive daytime sleepiness
-
-
results in significant improvement
#9
modafinil
no change
fatigue
-
-
not
#10
continuous positive airway pressure
neutral
sleep apnea
PD patients
-
trial was recently completed
#11
rotigotine patch
increase
early morning motor dysfunction and disrupted sleep
those patients with early morning motor dysfunction and disrupted sleep
-
provides significant benefit
#12
Abstract

Sleep disorders are common in patients with Parkinson's disease (PD), and preliminary work has suggested viable treatment options for many of these disorders. For rapid eye movement sleep behavior disorder, melatonin and clonazepam are most commonly used, while rivastigmine might be a useful option in patients whose behaviors are refractory to the former. Optimal treatments for insomnia in PD have yet to be determined, but preliminary evidence suggests that cognitive-behavioral therapy, light therapy, eszopiclone, donepezil, and melatonin might be beneficial. Use of the wake-promoting agent modafinil results in significant improvement in subjective measures of excessive daytime sleepiness, but not of fatigue. Optimal treatment of restless legs syndrome and obstructive sleep apnea in PD are not yet established, although a trial of continuous positive airway pressure for sleep apnea was recently completed in PD patients. In those patients with early morning motor dysfunction and disrupted sleep, the rotigotine patch provides significant benefit.

Medical Subject Headings (MeSH)
AnimalsHumansParkinson DiseaseSleep Wake Disorders
Study Links
Quality Scores
SafetyNot Assessed
Efficacy70/10
Quality60/10
Citation Metrics
Total Citations38
Citations/Year3.5
Relative Citation Ratio1.73
NIH Percentile69.9%
Research Impact Scores
APT Score0.75
Weight Score0.72
Normalized Score0.60
Related Supplements
Treatment of the sleep disorders associated with Parkinson's... | Panacea Index