Treatment of the sleep disorders associated with Parkinson's disease.
Study Goal
The researchers aimed to explore potential treatments, including light therapy, for insomnia in Parkinson's disease patients.
Results Summary
Preliminary evidence suggests light therapy might be beneficial for insomnia in Parkinson's disease, but optimal treatments are yet to be determined. The abstract does not provide detailed results specific to light therapy.
Population
Patients with Parkinson's disease experiencing sleep disorders, particularly insomnia.
Effective Dosage
Not available
Duration
Not available
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin | neutral | rapid eye movement sleep behavior disorder | patients with Parkinson's disease | - | most commonly used | #1 |
clonazepam | neutral | rapid eye movement sleep behavior disorder | patients with Parkinson's disease | - | most commonly used | #2 |
rivastigmine | neutral | rapid eye movement sleep behavior disorder | patients whose behaviors are refractory to the former | - | might be a useful option | #3 |
cognitive-behavioral therapy | neutral | insomnia | patients with Parkinson's disease | - | might be beneficial | #4 |
light therapy | neutral | insomnia | patients with Parkinson's disease | - | might be beneficial | #5 |
eszopiclone | neutral | insomnia | patients with Parkinson's disease | - | might be beneficial | #6 |
donepezil | neutral | insomnia | patients with Parkinson's disease | - | might be beneficial | #7 |
melatonin | neutral | insomnia | patients with Parkinson's disease | - | might be beneficial | #8 |
modafinil | increase | subjective measures of excessive daytime sleepiness | - | - | results in significant improvement | #9 |
modafinil | no change | fatigue | - | - | not | #10 |
continuous positive airway pressure | neutral | sleep apnea | PD patients | - | trial was recently completed | #11 |
rotigotine patch | increase | early morning motor dysfunction and disrupted sleep | those patients with early morning motor dysfunction and disrupted sleep | - | provides significant benefit | #12 |
Sleep disorders are common in patients with Parkinson's disease (PD), and preliminary work has suggested viable treatment options for many of these disorders. For rapid eye movement sleep behavior disorder, melatonin and clonazepam are most commonly used, while rivastigmine might be a useful option in patients whose behaviors are refractory to the former. Optimal treatments for insomnia in PD have yet to be determined, but preliminary evidence suggests that cognitive-behavioral therapy, light therapy, eszopiclone, donepezil, and melatonin might be beneficial. Use of the wake-promoting agent modafinil results in significant improvement in subjective measures of excessive daytime sleepiness, but not of fatigue. Optimal treatment of restless legs syndrome and obstructive sleep apnea in PD are not yet established, although a trial of continuous positive airway pressure for sleep apnea was recently completed in PD patients. In those patients with early morning motor dysfunction and disrupted sleep, the rotigotine patch provides significant benefit.