Effectiveness of mindfulness-based stress reduction and mindfulness based cognitive therapy in vascular disease: A systematic review and meta-analysis of randomised controlled trials.
Study Goal
To determine the effectiveness of mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) on psychological and physical outcomes for people with vascular disease.
Results Summary
The study found significant reductions in stress, depression, and anxiety, but effects on physical outcomes (e.g., blood pressure, albuminuria, stress hormones) were mixed. Psychological benefits were evident, but physical benefits were not conclusively established.
Population
People with vascular disease, including those with prehypertension/hypertension, type 1 or 2 diabetes, heart disease, and stroke.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) | decrease | stress | people with vascular disease | -0.36; 95% CI -0.67 to -0.09; p=0.01 | showed evidence of reductions | #1 |
mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) | decrease | depression | people with vascular disease | -0.35; 95% CI -0.53 to -0.16; p=0.003 | showed evidence of reductions | #2 |
mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) | decrease | anxiety | people with vascular disease | -0.50; 95% CI -0.70 to -0.29; p<0.001 | showed evidence of reductions | #3 |
mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) | no change | physical outcomes (blood pressure, albuminuria, stress hormones) | people with vascular disease | - | were mixed | #4 |
mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) | increase | psychological outcomes | populations with vascular disease | - | appear to derive a range of psychological benefits | #5 |
mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) | no change | effects on physical parameters of disease | populations with vascular disease | - | are not yet established | #6 |
OBJECTIVE: To determine the effectiveness of mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) on psychological and physical outcomes for people with vascular disease. DESIGN: Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES: AMED, CINAHL, EMBASE, British Nursing Index, Medline, Web of Science, PsycINFO, Cochrane Database of Systematic Reviews, Central, Social Sciences Citation Index, Social Policy and Practice, and HMIC from inception to January 2013. REVIEW METHODS: Articles were screened for inclusion independently by two reviewers. Data extraction and quality appraisal were performed by one reviewer and checked by a second with discrepancies resolved by discussion with a third if necessary. Random-effects meta-analyses were performed. RESULTS: Nine articles (from eight original randomised controlled trials) met eligibility criteria and were included in the final review. In total, 578 participants were enrolled across the trials, with participants presenting with prehypertension/hypertension (n=3 trials), type 1 or 2 diabetes (n=2), heart disease (n=2) and stroke (n=1). Meta-analyses, using standardised mean differences, showed evidence of reductions in stress (-0.36; 95% CI -0.67 to -0.09; p=0.01), depression (-0.35; 95% CI -0.53 to -0.16; p=0.003) and anxiety (-0.50; 95% CI -0.70 to -0.29; p<0.001). Effects on physical outcomes (blood pressure, albuminuria, stress hormones) were mixed. CONCLUSION: Whilst populations with vascular disease appear to derive a range of psychological benefits from MBSR/MBCT intervention, the effects on physical parameters of disease are not yet established. More robust studies, with longer term follow-up, are required to ascertain full effectiveness of such intervention.