Hypolipidic diet and phytosubstance supplement in hypercholesterolemia.
Study Goal
The researchers aimed to evaluate the effects of a low-fat diet, both alone and combined with phyto-supplements, on hyperlipidemia and nutritional status.
Results Summary
The low-fat diet alone (group D) significantly reduced BMI, waist and hip circumference, total cholesterol, and LDL cholesterol. The diet combined with phyto-supplements (group E) showed greater reductions in these metrics, particularly in cholesterol levels.
Population
191 hyperlipidemic patients attending outpatient clinics.
Effective Dosage
Not specified
Duration
6 months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
hypolipidic diet | decrease | BMI | patients affected by hyperlipidemia (group D) | 32.6 ± 0.7 vs. 34.3 ± 0.7 kg/m² | showed a significant reduction | #1 |
hypolipidic diet | decrease | waist circumference | patients affected by hyperlipidemia (group D) | 104.4 ± 1.6 vs. 108.3 ± 1.5 cm | showed a significant reduction | #2 |
hypolipidic diet | decrease | hip circumference | patients affected by hyperlipidemia (group D) | 107.9 ± 1.1 vs. 111.2 ± 1.1 cm | showed a significant reduction | #3 |
hypolipidic diet | decrease | total cholesterol | patients affected by hyperlipidemia (group D) | 214.2 ± 3.7 vs. 236.6 ± 2.2 mg/dL, -9.4 ± 68.2% | showed a significant reduction | #4 |
hypolipidic diet | decrease | LDL cholesterol | patients affected by hyperlipidemia (group D) | 133 ± 3 vs. 152.9 ± 2.8 mg/dL, -13 ± 7.1% | showed a significant reduction | #5 |
hypolipidic diet and supplement (red yeast, guggulsterones, flavonoid, sylimarin) | decrease | BMI | patients affected by hyperlipidemia (group E) | 30.2 ± 0.7 vs. 32.6 ± 0.6 kg/m² | showed a significant reduction | #6 |
hypolipidic diet and supplement (red yeast, guggulsterones, flavonoid, sylimarin) | decrease | waist circumference | patients affected by hyperlipidemia (group E) | 94.5 ± 1.6 vs. 101.3 ± 1.3 cm | showed a significant reduction | #7 |
hypolipidic diet and supplement (red yeast, guggulsterones, flavonoid, sylimarin) | decrease | hip circumference | patients affected by hyperlipidemia (group E) | 106.6 ± 1.1 vs. 110.5 ± 1 cm | showed a significant reduction | #8 |
hypolipidic diet and supplement (red yeast, guggulsterones, flavonoid, sylimarin) | decrease | total cholesterol | patients affected by hyperlipidemia (group E) | 212.4 ± 3.7 vs. 256.9 ± 2.1 mg/dL, -17.3 ± 76.2% | showed a significant reduction | #9 |
hypolipidic diet and supplement (red yeast, guggulsterones, flavonoid, sylimarin) | decrease | LDL cholesterol | patients affected by hyperlipidemia (group E) | 133.4 ± 3.4 vs. 168.4 ± 2.3 mg/dL, -20.8 ± 47.8% | showed a significant reduction | #10 |
Low fat diet, associated to phyto-substance supplement | decrease | serum cholesterol level | - | - | have been proven useful to decrease | #11 |
Low fat diet, associated to phyto-substance supplement | increase | nutritional status | - | - | have been proven useful to improve | #12 |
AIM: This study aimed to evaluate the effects of phyto-supplements on hyperlipidemia. METHODS: For this study 191 patients, affected by hyperlipidemia, attending the Outpatient Clinics of Clinical Medicine Department, were recruited. The patients were divided in two groups. The first group (80) has been treated with hypolipidic diet for six months (group D). The second one (111) has been administered with hypolipidic diet and supplement (red yeast, guggulsterones, flavonoid, sylimarin) (group E). Anthropometric measurements and bioimpedance analysis were evaluated before and after treatment. Moreover, total cholesterol, LDL, HDL, triglycerides (TG) and hepatic transaminases (AST, ALT) were measured before, after 3 and 6 months of treatment. RESULTS: D group showed a significant reduction in BMI (32.6 ± 0.7 vs. 34.3 ± 0.7 kg/m²), waist circumference (104.4 ± 1.6 vs. 108.3 ± 1.5 cm), hip circumference (107.9 ± 1.1 vs. 111.2 ± 1.1 cm), total cholesterol (214.2 ± 3.7 vs. 236.6 ± 2.2 mg/dL, -9.4 ± 68.2%), LDL cholesterol (133 ± 3 vs. 152.9 ± 2.8 mg/dL, -13 ± 7.1%). E group showed a significant reduction in BMI (30.2 ± 0.7 vs. 32.6 ± 0.6 kg/m²), waist circumference (94.5 ± 1.6 vs. 101.3 ± 1.3 cm), hip circumference (106.6 ± 1.1 vs. 110.5 ± 1 cm), total cholesterol (212.4 ± 3.7 vs. 256.9 ± 2.1 mg/dL, -17.3 ± 76.2%), LDL cholesterol (133.4 ± 3.4 vs. 168.4 ± 2.3 mg/dL, -20.8 ± 47.8%). CONCLUSION: Low fat diet, associated to phyto-substance supplement, have been proven useful to decrease serum cholesterol level and to improve nutritional status.