A modified portfolio diet complements medical management to reduce cardiovascular risk factors in diabetic patients with coronary artery disease.
Study Goal
The researchers aimed to determine the cardiovascular risk reduction effects of a Modified Portfolio Diet (MPD) in medically managed, high-risk patients with type II diabetes post-bypass surgery.
Results Summary
The MPD led to a 19% reduction in LDL cholesterol, significant drops in homocysteine levels, improved endothelial function, and increased endothelial progenitor cell numbers, with no significant changes observed in the control group.
Population
30 patients with type II diabetes, 6 weeks post-bypass surgery.
Effective Dosage
Low fat, 8 g/1000 kcal viscous fibres, 17 g/1000 kcal soy protein, and 22 g/1000 kcal almonds.
Duration
4 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Modified Portfolio Diet (MPD) | decrease | LDL | 30 patients with type II diabetes, 6 weeks post bypass surgery | 19% relative reduction (1.9 ± 0.8 vs 1.6 ± 0.6 mmol/L) | resulted in a 19% relative reduction | #1 |
Modified Portfolio Diet (MPD) | no change | HDL cholesterol | 30 patients with type II diabetes, 6 weeks post bypass surgery | no change | no change | #2 |
Modified Portfolio Diet (MPD) | decrease | Homocysteine levels | 30 patients with type II diabetes, 6 weeks post bypass surgery | 10.1 ± 2.7 vs 7.9 ± 4 μmol/L | dropped significantly | #3 |
Modified Portfolio Diet (MPD) | increase | Flow mediated dilatation | treated patients | 3.8 ± 3.8% to 6.5 ± 3.6% | increased significantly | #4 |
Modified Portfolio Diet (MPD) | increase | Endothelial progenitor cells numbers (CD34+, CD 133+ and UEA-1+) | 30 patients with type II diabetes, 6 weeks post bypass surgery | - | increased significantly | #5 |
Modified Portfolio Diet (MPD) | no change | migratory capacity | 30 patients with type II diabetes, 6 weeks post bypass surgery | no difference | no difference | #6 |
no diet therapy | no change | Flow mediated dilatation | Seven patients with no diet therapy served as time controls | remaining constant | showed no significant changes | #7 |
no diet therapy | no change | Endothelial progenitor cells numbers | Seven patients with no diet therapy served as time controls | no significant changes | showed no significant changes | #8 |
BACKGROUND & AIMS: Secondary prevention can improve outcomes in high risk patients. This study investigated the magnitude of cardiovascular risk reduction associated with consumption of a modified portfolio diet in parallel with medical management. DESIGN: 30 patients with type II diabetes, 6 weeks post bypass surgery received dietary counseling on a Modified Portfolio Diet (MPD) (low fat, 8 g/1000 kcal viscous fibres, 17 g/1000 kcal soy protein and 22 g/1000 kcal almonds). Lipid profiles, endothelial function and markers of glycemic control, oxidative stress and inflammation were measured at baseline and following two and four weeks of intervention. Seven patients with no diet therapy served as time controls. RESULTS: Consumption of the MPD resulted in a 19% relative reduction in LDL (1.9 ± 0.8 vs 1.6 ± 0.6 mmol/L, p < 0.001) with no change in HDL cholesterol. Homocysteine levels dropped significantly (10.1 ± 2.7 vs 7.9 ± 4 μmol/L, p = 0.006) over the study period. Flow mediated dilatation increased significantly in treated patients (3.8 ± 3.8% to 6.5 ± 3.6%, p = 0.004) while remaining constant in controls (p = 0.6). Endothelial progenitor cells numbers (CD34+, CD 133+ and UEA-1+) increased significantly following MPD consumption (p < 0.02) with no difference in migratory capacity. In contrast, time controls showed no significant changes. CONCLUSION: Dietary intervention in medically managed, high risk patients resulted in important reductions in risk factors. Clinical Trials registry number NCT00462436.