Effects of Mediterranean diet supplemented with silybin-vitamin E-phospholipid complex in overweight patients with non-alcoholic fatty liver disease.
Study Goal
The researchers aimed to compare the metabolic effects of a Mediterranean diet alone versus the diet combined with a complex containing phosphatidylcholine, silybin, and vitamin E in overweight patients with non-alcoholic fatty liver disease.
Results Summary
The Mediterranean diet, both alone and combined with the Realsil complex (containing phosphatidylcholine), led to significant improvements in BMI, waist circumference, total cholesterol, and triglycerides. Group B (diet + Realsil) also showed a statistically significant decrease in homeostasis model assessment technique.
Population
Thirty Caucasian overweight patients with non-alcoholic fatty liver disease.
Effective Dosage
Daily administration of Realsil complex (specific dosage not provided).
Duration
6 months.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Mediterranean diet | neutral | BMI | overweight patients with non-alcoholic fatty liver disease | - | significant variation | #1 |
Mediterranean diet | neutral | waist circumference | overweight patients with non-alcoholic fatty liver disease | - | significant variation | #2 |
Mediterranean diet | neutral | total cholesterol | overweight patients with non-alcoholic fatty liver disease | - | significant variation | #3 |
Mediterranean diet | neutral | triglycerides | overweight patients with non-alcoholic fatty liver disease | - | significant variation | #4 |
Mediterranean diet in association with Realsil complex | neutral | BMI | overweight patients with non-alcoholic fatty liver disease | - | significant variation | #5 |
Mediterranean diet in association with Realsil complex | neutral | waist circumference | overweight patients with non-alcoholic fatty liver disease | - | significant variation | #6 |
Mediterranean diet in association with Realsil complex | neutral | total cholesterol | overweight patients with non-alcoholic fatty liver disease | - | significant variation | #7 |
Mediterranean diet in association with Realsil complex | neutral | triglycerides | overweight patients with non-alcoholic fatty liver disease | - | significant variation | #8 |
Mediterranean diet in association with Realsil complex | decrease | homeostasis model assessment technique | Group B patients | - | statistically significant decrease | #9 |
BACKGROUND: Non-alcoholic fatty liver disease is the most common liver disease worldwide. AIM: The aim of this study is to compare the metabolic effects of the Mediterranean diet versus the diet associated with silybin, phosphatidylcholine and vitamin E complex in overweight patients with non-alcoholic fatty liver disease. METHODS: Thirty Caucasian overweight patients were randomized into three groups of 10 (Groups A, B and C). A personalized Mediterranean diet was started in Group A and B patients. In association with the diet, Group B patients were given Realsil complex, daily, for 6 months. Group C patients refused any treatment. RESULTS: We showed that the Mediterranean diet alone, or in association with the Realsil complex, led to the significant variation in BMI, waist circumference, total cholesterol and triglycerides. We also observed a statistically significant decrease in homeostasis model assessment technique in Group B patients.