Drugs that may harm bone: Mitigating the risk.
Study Goal
The researchers aimed to highlight the adverse effects of certain medications on bone health and the role of calcium supplementation in mitigating these effects.
Results Summary
The study found that several medications negatively impact bone health, suggesting calcium and vitamin D supplementation, weight-bearing exercise, and osteoporosis-prevention treatment as countermeasures.
Population
Patients on glucocorticoids, proton pump inhibitors, SSRIs, certain antiepileptic drugs, or aromatase inhibitors.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Glucocorticoids | decrease | bone | patients | - | have significant adverse effects | #1 |
proton pump inhibitors | decrease | bone | patients | - | have significant adverse effects | #2 |
selective serotonin reuptake inhibitors (SSRIs) | decrease | bone | patients | - | have significant adverse effects | #3 |
certain antiepileptic drugs | decrease | bone | patients | - | have significant adverse effects | #4 |
aromatase inhibitors | decrease | bone | patients | - | have significant adverse effects | #5 |
calcium and vitamin D | increase | bone health | patients on these agents | - | supplement their intake | #6 |
weight-bearing exercise | increase | bone health | patients on these agents | - | encourage | #7 |
osteoporosis-prevention treatment | increase | bone health | patients on these agents | - | initiate | #8 |
Glucocorticoids, proton pump inhibitors, selective serotonin reuptake inhibitors (SSRIs), certain antiepileptic drugs, and aromatase inhibitors have significant adverse effects on bone. Healthcare providers should monitor the bone health of patients on these agents, supplement their intake of calcium and vitamin D, encourage weight-bearing exercise, and initiate osteoporosis-prevention treatment as indicated.