Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy.
Study Goal
The researchers were attempting to determine the role of reactive species and free radicals in sepsis pathogenesis and potential implications for N-Acetylcysteine.
Results Summary
The abstract does not provide specific findings regarding N-Acetylcysteine's effects.
Population
Critically ill patients with sepsis.
Effective Dosage
Not mentioned
Duration
Not mentioned
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin | decrease | oxidative stress | critically ill patients | - | reduces | #1 |
melatonin | decrease | inflammatory response | critically ill patients | - | reduces | #2 |
melatonin | decrease | nitric oxide (NO) production | critically ill patients | - | reduces | #3 |
melatonin | decrease | peroxynitrite (ONOO-) production | critically ill patients | - | reduces | #4 |
melatonin | decrease | apoptosis | critically ill patients | - | reduces | #5 |
melatonin | increase | mitochondrial function | critically ill patients | - | improves | #6 |
melatonin | increase | energy metabolism | critically ill patients | - | improves | #7 |
melatonin | increase | immune response | critically ill patients | - | improves | #8 |
melatonin | increase | sleep quality | critically ill patients | - | improves | #9 |
melatonin | increase | circadian rhythm | critically ill patients | - | improves | #10 |
melatonin | decrease | mortality | critically ill patients | - | reduces | #11 |
melatonin | decrease | morbidity | critically ill patients | - | reduces | #12 |
melatonin | decrease | length of hospital stay | critically ill patients | - | reduces | #13 |
melatonin | decrease | healthcare costs | critically ill patients | - | reduces | #14 |
Sepsis is one of the main causes of death among critically ill patients. Sepsis pathogenesis includes infection by gram-negative and gram-positive bacteria, fungi, or both; exacerbated inflammatory response; hypotension, with potential to cause vasodilatory shock; and lesser delivery of oxygen to tissues due to impairment of oxygen utilization by cells. The participation of reactive species and/or free radicals such as nitric oxide (NO), peroxynitrite (ONOO