The effects of dietary approaches to stop hypertension diet on weight loss, anti-Müllerian hormone and metabolic profiles in women with polycystic ovary syndrome: A randomized clinical trial.
Study Goal
The researchers aimed to evaluate the effects of the DASH diet, which includes low-fat dairy products, on weight loss, AMH levels, and metabolic profiles in women with PCOS.
Results Summary
The DASH diet, rich in low-fat dairy, resulted in significant improvements in BMI, AMH levels, insulin metabolism, SHBG, FAI, NO, and MDA levels compared to the control diet.
Population
Overweight or obese women with polycystic ovary syndrome (PCOS).
Effective Dosage
Not specified (diet included 52%-55% carbohydrates, 16%-18% proteins, and 30% total fats, with low-fat dairy as part of the DASH diet).
Duration
12 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
low-calorie DASH diet | decrease | BMI | overweight or obese patients with PCOS | -1.6±0.5 vs -1.2±0.7 kg/m² | resulted in a significant decrease | #1 |
low-calorie DASH diet | decrease | serum AMH levels | overweight or obese patients with PCOS | -1.4±0.8 vs -0.6±0.5 ng/mL | resulted in a significant decrease | #2 |
low-calorie DASH diet | decrease | fasting insulin levels | overweight or obese patients with PCOS | -2.2±1.5 vs -0.5±0.7 μIU/mL | resulted in a significant decrease | #3 |
low-calorie DASH diet | decrease | HOMA-IR | overweight or obese patients with PCOS | -0.5±0.3 vs -0.1±0.2 | resulted in a significant decrease | #4 |
low-calorie DASH diet | decrease | serum triglycerides | overweight or obese patients with PCOS | -13.7±6.8 vs -3.1±5.1 mg/dL | resulted in a significant decrease | #5 |
low-calorie DASH diet | decrease | VLDL-cholesterol levels | overweight or obese patients with PCOS | -2.7±1.4 vs -0.6±1.0 mg/dL | resulted in a significant decrease | #6 |
low-calorie DASH diet | decrease | MDA levels | overweight or obese patients with PCOS | -0.5±0.2 vs -0.2±0.1 μmol/L | resulted in a significant decrease | #7 |
low-calorie DASH diet | increase | nitric oxide | overweight or obese patients with PCOS | 8.1±2.9 vs 2.1±1.6 μmol/L | resulted in a significant increase | #8 |
low-calorie DASH diet | increase | total antioxidant capacity | overweight or obese patients with PCOS | 75.8±15.6 vs 6.2±11.3 mmol/L | resulted in a significant increase | #9 |
low-calorie DASH diet | increase | glutathione levels | overweight or obese patients with PCOS | 111.7±35.8 vs 21.8±25.6 μmol/L | resulted in a significant increase | #10 |
low-calorie DASH diet | increase | SHBG levels | overweight or obese patients with PCOS | 8.1±3.1 vs 1.2±1.8 nmol/L | resulted in a significant increase | #11 |
low-calorie DASH diet | decrease | FAI | overweight or obese patients with PCOS | -0.03±0.01 vs -0.003±0.01 | resulted in a significant decrease | #12 |
OBJECTIVE: This study was designed to evaluate the effects of the dietary approaches to stop hypertension (DASH diet) on weight loss, anti-Müllerian hormone (AMH) and metabolic profiles in women with polycystic ovary syndrome (PCOS). DESIGN, PATIENTS AND MEASUREMENTS: A randomized controlled clinical trial was conducted among 60 overweight or obese patients with PCOS. Patients were randomly assigned to receive either low-calorie DASH (N=30) or control diet (N=30) for 12 weeks. The DASH and control diets were consisted of 52%-55% carbohydrates, 16%-18% proteins and 30% total fats; however, the DASH diet was designed to be rich in fruits, vegetables, whole grains, low-fat dairy products, cholesterol and refined grains. Both diets were equicaloric. RESULTS: Adherence to the DASH diet, compared to the control diet, resulted in a significant decrease in BMI (-1.6±0.5 vs -1.2±0.7 kg/m CONCLUSIONS: Adherence to the DASH diet for 12 weeks among PCOS women had beneficial effects on BMI, AMH, insulin metabolism, SHBG, FAI, NO and MDA levels.