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Vitamin D in obesity.

Current opinion in endocrinology, diabetes, and obesity
December 1, 2017
Jennifer S Walsh et al. (3 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to understand the mechanism behind lower serum vitamin D levels in obese individuals and whether bariatric surgery affects bone health in these patients.

Results Summary

The study found that lower vitamin D levels in obese individuals likely result from volumetric dilution rather than clinical deficiency. Bariatric surgery patients experience bone loss, but ensuring vitamin D sufficiency may help mitigate this effect.

Population

Obese individuals, including those undergoing bariatric surgery.

Effective Dosage

Higher loading doses of vitamin D are needed for obese individuals to achieve normal serum levels (specific dosage not provided).

Duration

Not specified.

Interactions

None mentioned.

Extracted Claims (11)
InterventionDirectionEndpointPopulationDosageImpactClaim #
Vitamin D supplementation
neutral
bone health
-
-
is essential for
#1
Vitamin D
neutral
immunity and other systems
-
-
may also have important functions in
#2
-
decrease
serum vitamin D
obese people
-
is lower in
#3
-
neutral
volumetric dilution effect
obese people
-
likely reflects
#4
-
no change
whole body stores of vitamin D
obese people
-
may be adequate
#5
-
no change
bone turnover
obese adults
-
do not have higher
#6
-
no change
bone mineral density
obese adults
-
do not have lower
#7
-
increase
bone loss
patients undergoing bariatric surgery
-
do have
#8
ensuring vitamin D sufficiency
decrease
bone loss
patients undergoing bariatric surgery
-
may help to attenuate
#9
-
decrease
lower vitamin D
obese people
-
is a consistent finding
#10
-
increase
vitamin D
obese people
-
need higher loading doses of
#11
Abstract

PURPOSE OF REVIEW: Vitamin D is essential for bone health, and may also have important functions in immunity and other systems. Vitamin D deficiency is common, and testing and supplementation is increasing. Serum vitamin D is lower in obese people; it is important to understand the mechanism of this effect and whether it indicates clinically significant deficiency. RECENT FINDINGS: Vitamin D is fat soluble, and distributed into fat, muscle, liver, and serum. All of these compartments are increased in volume in obesity, so the lower vitamin D likely reflects a volumetric dilution effect and whole body stores of vitamin D may be adequate. Despite lower serum vitamin D, obese adults do not have higher bone turnover or lower bone mineral density. Patients undergoing bariatric surgery do have bone loss, and ensuring vitamin D sufficiency in these patients may help to attenuate bone loss. SUMMARY: Lower vitamin D in obese people is a consistent finding across age, ethnicity, and geography. This may not always reflect a clinical problem. Obese people need higher loading doses of vitamin D to achieve the same serum 25-hydroxyvitamin D as normal weight.

Medical Subject Headings (MeSH)
AdultBariatric SurgeryBone RemodelingBone and BonesFemaleHumansMaleObesityVitamin DVitamin D Deficiency
Study Links
Quality Scores
SafetyNot Assessed
Efficacy70/10
Quality75/10
Citation Metrics
Total Citations167
Citations/Year20.9
Relative Citation Ratio8.61
NIH Percentile97.2%
Research Impact Scores
APT Score0.95
Weight Score2.22
Normalized Score0.63
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