Effects of Low-Protein Diet on lipid and anthropometric profiles of patients with chronic kidney disease on conservative management.
Study Goal
The researchers aimed to evaluate the effects of a low-protein diet (LPD) on lipid and anthropometric profiles in non-dialysis chronic kidney disease (CKD) patients.
Results Summary
After six months of LPD, patients showed significant reductions in BMI, total cholesterol, LDL, and uric acid, along with improved glomerular filtration rate (GFR). The diet also reduced energy, protein, cholesterol, and fiber intake.
Population
Non-dialysis CKD patients (40 participants, 20 men, mean age 62.7 ± 15.2 years, GFR 26.16 ± 9.4 mL/min/1.73m²).
Effective Dosage
0.6g/kg/day of protein.
Duration
Six months.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
low protein diet (LPD) | decrease | body mass index (BMI) | non-dialysis CKD patients | from 28.1 ± 5.6 to 27.0 ± 5.3 Kg/m2 | reduction | #1 |
low protein diet (LPD) | decrease | total cholesterol | non-dialysis CKD patients | from 199.7 ± 57.1 to 176.0 ± 43.6mg/dL | reduction | #2 |
low protein diet (LPD) | decrease | LDL | non-dialysis CKD patients | from 116.2 ± 48.1 to 97.4 ± 39.1 mg/dL | reduction | #3 |
low protein diet (LPD) | decrease | uric acid | non-dialysis CKD patients | from 6.8 ± 1.4 to 6.2 ± 1.3 mg/dL | reduction | #4 |
low protein diet (LPD) | increase | glomerular filtration rate (GFR) | non-dialysis CKD patients | from 26.2 ± 9.5 to 28.9 ± 12.7mL/min | increased | #5 |
low protein diet (LPD) | decrease | energy intake | non-dialysis CKD patients | - | reduced significantly | #6 |
low protein diet (LPD) | decrease | proteins intake | non-dialysis CKD patients | - | reduced significantly | #7 |
low protein diet (LPD) | decrease | cholesterol intake | non-dialysis CKD patients | - | reduced significantly | #8 |
low protein diet (LPD) | decrease | fiber intake | non-dialysis CKD patients | - | reduced significantly | #9 |
INTRODUCTION: Chronic Kidney disease (CKD) patients have a high prevalence of cardiovascular mortality, and among the risk factors are dyslipidemia and obesity, common findings in the early stages of CKD. The aim of this study was to evaluate the effects of low protein diet (LPD) on the lipid and anthropometric profile in non-dialysis CKD patients. METHODS: Forty CKD patients were studied (20 men, 62.7 ± 15.2 years, glomerular filtration rate (GFR) 26.16 ± 9.4 mL/min/1.73m2). LPD (0.6g/kg/d) was prescribed for six months and, biochemical and anthropometric parameters like body mass index (BMI), waist circumference and body fat mass (assessed by dual X-ray absorptiometry - DXA) were evaluated before and after six months with LPD. RESULTS: After six months of nutritional intervention, patients presented reduction on BMI (from 28.1 ± 5.6 to 27.0 ± 5.3 Kg/m2, p = 0.001), total cholesterol (from 199.7 ± 57.1 to 176.0 ± 43.6mg/dL, p = 0.0001), LDL (from 116.2 ± 48.1 to 97.4 ± 39.1 mg/dL, p = 0,001) and uric acid (from 6.8 ± 1.4 to 6.2 ± 1.3 mg/dL, p = 0.004). In addition, GFR values were increased from 26.2 ± 9.5 to 28.9 ± 12.7mL/min (p = 0.02). The energy, proteins, cholesterol and fiber intake were reduced significantly. CONCLUSION: LPD prescribe to non-dialysis CKD patients for six months was able to improve some cardiovascular risk factors as overweight and plasma lipid profile, suggesting that LPD can be also an important tool for protection against cardiovascular diseases in these patients.