Effect of Monacolin K and COQ10 supplementation in hypertensive and hypercholesterolemic subjects with metabolic syndrome.
Study Goal
The researchers aimed to determine whether Coenzyme Q10, combined with red yeast rice and added to diet and lifestyle management, was more effective than diet alone in improving blood pressure, lipid, and glucose profiles in patients with metabolic syndrome.
Results Summary
The study found that Coenzyme Q10 supplementation significantly improved systolic and diastolic blood pressure, total cholesterol, LDL cholesterol, triglycerides, and glucose levels compared to diet alone, with no significant changes in HDL cholesterol. The treatment was well-tolerated and safe.
Population
104 subjects with metabolic syndrome (mean age 57.4 ± 8.8 years, 51% males) without a history of cardiovascular diseases.
Effective Dosage
Once-daily oral formulation (specific dosage not detailed).
Duration
2 months.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
NCs containing red yeast rice and coenzyme Q10 added to diet | decrease | BP, TC, TG, LDLC and glucose levels | 104 subjects with MetS without history of cardio-vascular diseases | - | A significant reduction | #1 |
NCs containing red yeast rice and coenzyme Q10 added to diet | decrease | systolic BP | 52 subjects treated with NCs | -5.2 vs. -3.0 mmHg | a greater reduction | #2 |
NCs containing red yeast rice and coenzyme Q10 added to diet | decrease | diastolic BP | 52 subjects treated with NCs | -4.9 vs. 2.9 mmHg | a greater reduction | #3 |
NCs containing red yeast rice and coenzyme Q10 added to diet | decrease | total cholesterol | 52 subjects treated with NCs | -17.2% | a greater reduction | #4 |
NCs containing red yeast rice and coenzyme Q10 added to diet | decrease | LDLC | 52 subjects treated with NCs | -21.8% | a greater reduction | #5 |
NCs containing red yeast rice and coenzyme Q10 added to diet | decrease | TG | 52 subjects treated with NCs | -16.0% | a greater reduction | #6 |
NCs containing red yeast rice and coenzyme Q10 added to diet | decrease | serum glucose | 52 subjects treated with NCs | -3.4% | a greater reduction | #7 |
NCs containing red yeast rice and coenzyme Q10 added to diet | no change | HDLC | 52 subjects treated with NCs | - | remained unchanged | #8 |
diet program | decrease | BP, TC, TG, LDLC and glucose levels | 52 patients following a diet program | - | A significant reduction | #9 |
NC supplementation | increase | clinic BP, lipid and glucose profile | patients with MetS | - | effective in improving | #10 |
INTRODUCTION: Metabolic syndrome (MetS) is a world-wide epidemic disease with an increased risk of morbidity and mortality. Treatment strategies of MetS include pharmacologic and non-pharmacologic interventions and in this respect a relevant role has been shown for nutraceutical compounds (NCs). The aim of this study was to investigate the efficacy and safety of NCs incorporated with diet and lifestyle management versus diet alone, in lowering blood pressure (BP) values and improving lipid and glucose profile, in a group of hypertensives and hyper-cholesterolemic patients with MetS. METHODS: 104 subjects with MetS (mean age 57.4 ± 8.8 years, 51% males) without history of cardio-vascular (CV) diseases were enrolled in the study. 52 subjects were treated with a once-daily oral formulation of a NCs containing red yeast rice and coenzyme Q10 added to their diet for 2 months and were compared with the 52 patients following a diet program. Differences in BP, serum total cholesterol (TC), low- and high-density-lipoprotein cholesterol (LDLC and HDLC), triglycerides (TG) and glucose values were compared by analysis of variance. RESULTS: A significant reduction of BP, TC, TG, LDLC and glucose levels was observed in both treatment groups. However, a greater reduction of systolic BP (-5.2 vs. -3.0 mmHg), diastolic BP (-4.9 vs. 2.9 mmHg), total cholesterol (-17.2%), LDLC (-21.8%), TG (-16.0%) and serum glucose (-3.4%) was observed in the treatment group relative to the control (p < 0.001 for all); HDLC remained unchanged (p = N.S.). Gender difference was not found in either group (p = N.S.). CONCLUSIONS: In patients with MetS, NC supplementation was safe, well tolerated and effective in improving clinic BP, lipid and glucose profile.