A Comparison of a Pulse-Based Diet and the Therapeutic Lifestyle Changes Diet in Combination with Exercise and Health Counselling on the Cardio-Metabolic Risk Profile in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial.
Study Goal
The researchers aimed to compare the effects of a pulse-based diet (including chickpeas) versus the TLC diet on cardio-metabolic measures in women with PCOS.
Results Summary
The pulse-based diet group showed greater reductions in insulin response and insulin resistance compared to the TLC group, indicating potential metabolic benefits of chickpeas in this population.
Population
Women aged 18-35 with polycystic ovary syndrome (PCOS).
Effective Dosage
Not specified (part of a pulse-based diet including lentils, beans, split peas, and chickpeas).
Duration
16 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
low-glycemic index pulse-based diet | decrease | total area under the curve for insulin response to a 75-g oral glucose tolerance test | women with polycystic ovary syndrome (PCOS) | -121.0 ± 229.9 vs. -27.4 ± 110.2 µIU/mL × min | greater reduction | #1 |
low-glycemic index pulse-based diet | decrease | insulin resistance | women with polycystic ovary syndrome (PCOS) | -0.3 ± 0.6 vs. -0.1 ± 0.4 | greater reduction | #2 |
low-glycemic index pulse-based diet | decrease | total cholesterol | women with polycystic ovary syndrome (PCOS) | -0.4 ± 0.6 vs. -0.1 ± 0.5 mmol/L | greater reduction | #3 |
low-glycemic index pulse-based diet | decrease | low-density lipoprotein cholesterol | women with polycystic ovary syndrome (PCOS) | -0.3 ± 0.5 vs. -0.1 ± 0.4 mmol/L | greater reduction | #4 |
low-glycemic index pulse-based diet | decrease | apolipoprotein B | women with polycystic ovary syndrome (PCOS) | -0.05 ± 0.11 vs. -0.01 ± 0.09 g/L | greater reduction | #5 |
low-glycemic index pulse-based diet | decrease | apolipoprotein B:apolipoprotein A1 ratio | women with polycystic ovary syndrome (PCOS) | -0.04 ± 0.09 vs. -0.01 ± 0.07 | greater reduction | #6 |
low-glycemic index pulse-based diet | decrease | systolic blood pressure | women with polycystic ovary syndrome (PCOS) | -5 ± 8 vs. -1 ± 7 mmHg | greater reduction | #7 |
low-glycemic index pulse-based diet | decrease | diastolic blood pressure | women with polycystic ovary syndrome (PCOS) | -3 ± 6 vs. -1 ± 5 mmHg | greater reduction | #8 |
low-glycemic index pulse-based diet | decrease | high-sensitivity C-reactive protein | women with polycystic ovary syndrome (PCOS) | -0.3 ± 1.5 vs. 0.2 ± 1.4 mg/L | greater reduction | #9 |
low-glycemic index pulse-based diet | decrease | body weight | women with polycystic ovary syndrome (PCOS) | -3.4 ± 3.0 vs. -1.8 ± 2.6 kg | greater reduction | #10 |
low-glycemic index pulse-based diet | decrease | body mass index | women with polycystic ovary syndrome (PCOS) | -1.3 ± 1.1 vs. -0.7 ± 1.0 kg/m² | greater reduction | #11 |
low-glycemic index pulse-based diet | decrease | waist circumference | women with polycystic ovary syndrome (PCOS) | -3.6 ± 3.8 vs. -1.7 ± 3.5 cm | greater reduction | #12 |
low-glycemic index pulse-based diet | decrease | waist-to-hip ratio | women with polycystic ovary syndrome (PCOS) | -0.02 ± 0.03 vs. -0.01 ± 0.03 | greater reduction | #13 |
low-glycemic index pulse-based diet | decrease | body fat percentage | women with polycystic ovary syndrome (PCOS) | -1.3 ± 1.8 vs. -0.5 ± 1.7% | greater reduction | #14 |
low-glycemic index pulse-based diet | decrease | android fat percentage | women with polycystic ovary syndrome (PCOS) | -1.6 ± 2.3 vs. -0.6 ± 2.1% | greater reduction | #15 |
low-glycemic index pulse-based diet | decrease | gynoid fat percentage | women with polycystic ovary syndrome (PCOS) | -1.0 ± 1.6 vs. -0.4 ± 1.5% | greater reduction | #16 |
low-glycemic index pulse-based diet | decrease | android-to-gynoid fat ratio | women with polycystic ovary syndrome (PCOS) | -0.01 ± 0.03 vs. -0.003 ± 0.03 | greater reduction | #17 |
UNLABELLED: We compared the effects of a low-glycemic index pulse-based diet, containing lentils, beans, split peas, and chickpeas, to the Therapeutic Lifestyle Changes (TLC) diet on cardio-metabolic measures in women with polycystic ovary syndrome (PCOS). Ninety-five women (18⁻35 years) enrolled in a 16-week intervention; 30 women in the pulse-based and 31 in the TLC groups completed the study. Women participated in aerobic exercise training (minimum 5 days/week for 45 min/day) and were counselled (monthly) about PCOS and lifestyle modification. Women underwent longitudinal follow-up post-intervention. The pulse-based group had a greater reduction in total area under the curve for insulin response to a 75-g oral glucose tolerance test (mean change ± SD: -121.0 ± 229.9 vs. -27.4 ± 110.2 µIU/mL × min; TRIAL REGISTRATION: CinicalTrials.gov identifier, NCT01288638.