The Effect of Gluten Free Diet on Components of Metabolic Syndrome: A Randomized Clinical Trial.
Study Goal
The researchers aimed to assess the effects of a Gluten-Free Diet (GFD) on components of metabolic syndrome (MES).
Results Summary
The study found that a short-term GFD significantly reduced fasting blood glucose, waist circumference, and serum triglyceride levels compared to a regular diet, but had no significant effects on LDL cholesterol, total cholesterol, fasting insulin, HOMA-IR, or blood pressure.
Population
50 subjects diagnosed with metabolic syndrome (45 completed the study).
Effective Dosage
Not specified
Duration
8 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Gluten free diet (GFD) | no change | LDL cholesterol | subjects diagnosed with MES | no significant change | showed no effects | #1 |
Gluten free diet (GFD) | no change | total cholesterol | subjects diagnosed with MES | no significant change | showed no effects | #2 |
Gluten free diet (GFD) | no change | fasting insulin | subjects diagnosed with MES | no significant change | showed no effects | #3 |
Gluten free diet (GFD) | no change | HOMA-IR | subjects diagnosed with MES | no significant change | showed no effects | #4 |
Gluten free diet (GFD) | no change | systolic blood pressure | subjects diagnosed with MES | no significant change | showed no effects | #5 |
Gluten free diet (GFD) | no change | diastolic blood pressure | subjects diagnosed with MES | no significant change | showed no effects | #6 |
Gluten free diet (GFD) | decrease | fasting blood glucose | subjects diagnosed with MES | - | reduced | #7 |
Gluten free diet (GFD) | decrease | waist circumference (WC) | subjects diagnosed with MES | - | reduced | #8 |
Gluten free diet (GFD) | decrease | serum triglyceride concentration | subjects diagnosed with MES | - | reduced | #9 |
Gluten free diet (GFD) | increase | glycemic control | subjects with the metabolic syndrome | - | improved | #10 |
Gluten free diet (GFD) | increase | Triglyceride level | subjects with the metabolic syndrome | - | improved | #11 |
Background: This study aimed to assess the effects of Gluten free diet (GFD) on components of metabolic syndrome (MES). Materials and Methods: In this randomized clinical trial, 50 subjects diagnosed with MES were randomly divided into two groups (n=25). The first group received a GFD and the second group continued their regular diet. Biochemical markers of MES and blood pressure were measured before and after 8-week intervention. Results: Forty five subjects completed the study. A post-hoc comparison of the groups showed no effects of the GFD and control diet on LDL cholesterol, total cholesterol, fasting insulin, HOMA-IR, systolic and diastolic blood pressure levels. The GFD reduced fasting blood glucose, waist circumference (WC) and serum triglyceride concentration significantly compared with the control diet (p<0.05). Conclusion: Short-term GFD reduced WC and improved glycemic control and Triglyceride level in subjects with the metabolic syndrome.