The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Study Goal
The researchers aimed to determine the effect of melatonin supplementation on glycemic control through a systematic review and meta-analysis of randomized controlled trials.
Results Summary
The study analyzed multiple RCTs to assess melatonin's impact on glycemic control, but the abstract does not specify the exact findings regarding its effectiveness.
Population
Not specified in the abstract.
Effective Dosage
Not specified in the abstract.
Duration
Not specified in the abstract.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin supplementation | decrease | fasting blood glucose | - | - | significantly reduced | #1 |
melatonin supplementation | decrease | homeostatic model assessment of insulin resistance (HOMA-IR) | - | - | significantly reduced | #2 |
melatonin supplementation | decrease | glycated hemoglobin (HbA1c) | - | - | significantly reduced | #3 |
melatonin supplementation | increase | insulin levels | - | - | significantly increased | #4 |
melatonin supplementation | decrease | fasting blood glucose | patients with metabolic diseases | - | significantly reduced | #5 |
melatonin supplementation | decrease | homeostatic model assessment of insulin resistance (HOMA-IR) | patients with metabolic diseases | - | significantly reduced | #6 |
melatonin supplementation | decrease | glycated hemoglobin (HbA1c) | patients with metabolic diseases | - | significantly reduced | #7 |
melatonin supplementation | increase | insulin levels | patients with metabolic diseases | - | significantly increased | #8 |
This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to clarify the effect of melatonin supplementation on glycemic control. Databases including PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials were searched until July 30th, 2018. Two reviewers independently assessed study eligibility, extracted data, and evaluated the risk of bias for included trials. Heterogeneity among included studies was assessed using Cochran's Q test and I-square (I