Efficacy of melatonin on sleep quality after laparoscopic cholecystectomy.
Study Goal
The researchers aimed to determine whether melatonin improves sleep quality in patients undergoing laparoscopic cholecystectomy by reducing sleep latency and increasing total sleep duration.
Results Summary
Melatonin significantly decreased sleep latency (13.6 ± 14.95 min vs. 20.10 ± 16.18 min in placebo) and increased total sleep duration compared to placebo, indicating improved sleep quality post-surgery.
Population
Patients undergoing laparoscopic cholecystectomy (100 participants).
Effective Dosage
6 mg melatonin tablets taken 45 minutes before sleep.
Duration
3 days after surgery.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin | decrease | sleep latency (SL) | patients undergoing laparoscopic cholecystectomy (LC) | 13.6 ± 14.95 vs. 20.10 ± 16.18 min | results in decrease | #1 |
melatonin | increase | quality of sleep | patients undergoing laparoscopic cholecystectomy (LC) | - | could improve | #2 |
melatonin | decrease | SL | patients undergoing laparoscopic cholecystectomy (LC) | - | decreasing | #3 |
melatonin | increase | TSD | patients undergoing laparoscopic cholecystectomy (LC) | - | increasing | #4 |
CONTEXT: Postoperative sleep and circadian rhythm disturbances were associated with prolonged postoperative convalescence, respiratory, and cardiovascular morbidity. Sleep disturbances have been shown to be due to decreased levels of circulating melatonin after surgery. If this sleep pattern and circadian rhythm are recycled, outcome after surgery could be improved. AIMS: The aim of this study was to observe the effect of melatonin on the quality of sleep in patients undergoing laparoscopic cholecystectomy (LC). SUBJECTS AND METHODS: Hundred patients of LC participated in this randomized, placebo-controlled, double-blind, clinical trial. Patients were randomized equally into Group A who received 6 mg melatonin tablets 45 min before sleep for 3 days after surgery and Group B who received placebo. RESULTS: Melatonin usage results in decrease in sleep latency (SL) as compared to placebo (13.6 ± 14.95 vs. 20.10 ± 16.18 min, CONCLUSIONS: Results in this study could demonstrate that melatonin as a single agent could improve the quality of sleep after LC by decreasing SL and increasing TSD.