Whey protein supplementation reducing fasting levels of anandamide and 2-AG without weight loss in pre-menopausal women with obesity on a weight-loss diet.
Study Goal
The researchers aimed to determine the effects of whey protein supplementation combined with a weight-loss diet on endocannabinoid levels and metabolic parameters in obese women.
Results Summary
The study found that whey protein supplementation alongside a hypocaloric diet significantly reduced waist circumference, body fat, fasting blood sugar, endocannabinoids (AEA and 2-AG), total cholesterol, and triglycerides, while increasing HDL-c, compared to the control group. However, no significant differences were observed in body weight or BMI between groups.
Population
Obese women (n=60, aged not specified).
Effective Dosage
30 g/day of whey protein powder.
Duration
2 months.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
whey protein powders (30 g/day) and isocaloric weight-loss diet | decrease | WC | obese women | - | decreased | #1 |
whey protein powders (30 g/day) and isocaloric weight-loss diet | decrease | body fat | obese women | - | decreased | #2 |
whey protein powders (30 g/day) and isocaloric weight-loss diet | decrease | FBS | obese women | - | decreased | #3 |
whey protein powders (30 g/day) and isocaloric weight-loss diet | decrease | AEA | obese women | - | decreased | #4 |
whey protein powders (30 g/day) and isocaloric weight-loss diet | decrease | 2-AG | obese women | - | decreased | #5 |
whey protein powders (30 g/day) and isocaloric weight-loss diet | decrease | total cholesterol | obese women | - | decreased | #6 |
whey protein powders (30 g/day) and isocaloric weight-loss diet | decrease | triglyceride | obese women | - | decreased | #7 |
whey protein powders (30 g/day) and isocaloric weight-loss diet | increase | HDL-c | obese women | - | significantly increased | #8 |
whey protein powders (30 g/day) and isocaloric weight-loss diet | no change | body weight | obese women | - | did not show significant reductions | #9 |
whey protein powders (30 g/day) and isocaloric weight-loss diet | no change | BMI | obese women | - | did not show significant reductions | #10 |
BACKGROUND: Despite the importance of dairy proteins in modifying of metabolic abnormalities, no attention has been given to their effects on endocannabinoids. METHODS: A total number of 60 obese women were recruited in a 2-month randomized clinical trial. Following random allocation, they were assigned to one of the two groups: control (n = 30) and intervention (n = 30). Then, all the subjects followed a hypocaloric diet of 800 kcal below estimated energy needs. The intervention group received isocaloric weight-loss diet and whey protein powders (30 g/day). Baseline and 2-month fasting anthropometric, blood glucose, serum insulin, insulin resistance, lipid profile, AEA, and 2-AG were measured. RESULTS: The study groups were homogenous in terms of baseline characteristics (p > 0.05) except for MUFA intake (p = 0.021). There were no significant differences in energy and macronutrient intakes in the intervention group compared to the control group at the end of the study (p > 0.05). The results of the ANCOVA did not show significant reductions in body weight and BMI of the intervention group compared to the control group (p > 0.05); however, WC, body fat, FBS, AEA, 2-AG, total cholesterol, and triglyceride decreased and HDL-c significantly increased in the intervention group compared to the control group (p < 0.05). CONCLUSIONS: In this study, the effects of simultaneous weight-loss diet and whey protein supplementation on the reduction of endocannabinoids were determined. TRIAL REGISTRATION: Iranian Registry of Clinical Trials IRCT2017021410181N8 . Registered on March 2017.