Adverse effects of androgen deprivation therapy in patients with prostate cancer: Focus on muscle and bone health.
Study Goal
The researchers aimed to evaluate the role of calcium supplementation in improving bone health for patients undergoing androgen deprivation therapy (ADT) for prostate cancer.
Results Summary
The study suggests that calcium supplementation, along with vitamin D and lifestyle modifications, can improve bone health in ADT patients, though supervised exercise was highlighted as the primary intervention for mitigating ADT's adverse effects.
Population
Patients receiving androgen deprivation therapy (ADT) for prostate cancer.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Androgen deprivation therapy (ADT) | increase | hypogonadism | patients with prostate cancer | - | lead to | #1 |
Androgen deprivation therapy (ADT) | increase | obesity | patients with prostate cancer | - | lead to | #2 |
Androgen deprivation therapy (ADT) | increase | metabolic syndrome | patients with prostate cancer | - | lead to | #3 |
Androgen deprivation therapy (ADT) | increase | osteoporosis | patients with prostate cancer | - | lead to | #4 |
Androgen deprivation therapy (ADT) | increase | sarcopenia | patients with prostate cancer | - | lead to | #5 |
Androgen deprivation therapy (ADT) | increase | diabetes mellitus | patients with prostate cancer | - | lead to | #6 |
Androgen deprivation therapy (ADT) | increase | cardiovascular disease | patients with prostate cancer | - | lead to | #7 |
Androgen deprivation therapy (ADT) | increase | gynecomastia | patients with prostate cancer | - | lead to | #8 |
Androgen deprivation therapy (ADT) | increase | sexual dysfunction | patients with prostate cancer | - | lead to | #9 |
Androgen deprivation therapy (ADT) | decrease | quality of life | patients with prostate cancer | - | may have a significant impact on | #10 |
Androgen deprivation therapy (ADT) | decrease | life expectancy | patients with prostate cancer | - | may have a significant impact on | #11 |
supervised exercise | decrease | adverse effects of the ADT | patients receiving ADT | - | seems to be the only intervention that could prevent | #12 |
supervised exercise | increase | quality of life | patients receiving ADT | - | improve | #13 |
Lifestyle modification | increase | bone health | patients receiving ADT | - | improve | #14 |
supplementation of calcium | increase | bone health | patients receiving ADT | - | improve | #15 |
supplementation of vitamin D | increase | bone health | patients receiving ADT | - | improve | #16 |
antiosteoporotic treatments | increase | bone health | patients receiving ADT | - | improve | #17 |
Androgen deprivation therapy (ADT) is the most effective systemic treatment for prostate cancer and can be succeeded either surgically or pharmaceutically. Both approaches lead to hypogonadism with a large variety of adverse events, including obesity, metabolic syndrome, osteoporosis, sarcopenia, diabetes mellitus, cardiovascular disease, gynecomastia and sexual dysfunction. In addition, undesirable effects on muscle and bone health may have a significant impact not only on the quality of life but also on life expectancy. Currently, supervised exercise seems to be the only intervention that could prevent the adverse effects of the ADT and improve quality of life. Lifestyle modification, supplementation of calcium, vitamin D and when indicated antiosteoporotic treatments improve bone health. However, patients receiving ADT must be well informed about the potential benefits as well as the risks of the treatment.