Impact of a low-carbohydrate and high-fiber diet on nonalcoholic fatty liver disease.
Study Goal
The researchers aimed to determine the effects of a low-carbohydrate and high-fiber diet combined with education on metabolic indicators, including serum alanine aminotransferase levels, in patients with nonalcoholic fatty liver disease.
Results Summary
The study found that the intervention significantly reduced serum alanine aminotransferase levels, along with improvements in body weight, body fat, and other metabolic markers, particularly in female patients.
Population
44 patients with nonalcoholic fatty liver disease, divided by sex (male and female).
Effective Dosage
Not specified
Duration
2 months
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
low-carbohydrate and high-fiber diet and education | decrease | body fat | patients with nonalcoholic fatty liver disease | - | were significantly lower than before | #1 |
low-carbohydrate and high-fiber diet and education | decrease | body weight | patients with nonalcoholic fatty liver disease | - | were significantly lower than before | #2 |
low-carbohydrate and high-fiber diet and education | decrease | abdominal circumference | patients with nonalcoholic fatty liver disease | - | were significantly lower than before | #3 |
low-carbohydrate and high-fiber diet and education | decrease | visceral fat area | patients with nonalcoholic fatty liver disease | - | were significantly lower than before | #4 |
low-carbohydrate and high-fiber diet and education | decrease | fasting plasma glucose | patients with nonalcoholic fatty liver disease | - | were significantly lower than before | #5 |
low-carbohydrate and high-fiber diet and education | decrease | insulin resistance index | patients with nonalcoholic fatty liver disease | - | were significantly lower than before | #6 |
low-carbohydrate and high-fiber diet and education | decrease | serum alanine aminotransferase | patients with nonalcoholic fatty liver disease | - | were significantly lower than before | #7 |
low-carbohydrate and high-fiber diet and education | decrease | aspartate transaminase | patients with nonalcoholic fatty liver disease | - | were significantly lower than before | #8 |
low-carbohydrate and high-fiber diet and education | decrease | uric acid | patients with nonalcoholic fatty liver disease | - | were significantly lower than before | #9 |
low-carbohydrate and high-fiber diet and education | decrease | insulin | patients with nonalcoholic fatty liver disease | - | were significantly lower than before | #10 |
low-carbohydrate and high-fiber diet and education | decrease | insulin resistance index | female patients with nonalcoholic fatty liver disease | - | were lower | #11 |
low-carbohydrate and high-fiber diet and education | decrease | serum alanine aminotransferase | female patients with nonalcoholic fatty liver disease | - | were lower | #12 |
low-carbohydrate and high-fiber diet and education | decrease | uric acid | female patients with nonalcoholic fatty liver disease | - | were lower | #13 |
low-carbohydrate and high-fiber diet and education | decrease | triglyceride | female patients with nonalcoholic fatty liver disease | - | were lower | #14 |
low-carbohydrate and high-fiber diet and education | decrease | fasting plasma glucose | female patients with nonalcoholic fatty liver disease | - | were lower | #15 |
low-carbohydrate and high-fiber diet and education | decrease | C-peptide | female patients with nonalcoholic fatty liver disease | - | were lower | #16 |
low-carbohydrate and high-fiber diet and education | increase | serum high-density lipoprotein cholesterol | female patients with nonalcoholic fatty liver disease | - | was higher | #17 |
low-carbohydrate and high-fiber diet and education | decrease | serum alanine aminotransferase | male patients with nonalcoholic fatty liver disease | - | were lower | #18 |
low-carbohydrate and high-fiber diet and education | decrease | triglyceride | male patients with nonalcoholic fatty liver disease | - | were lower | #19 |
low-carbohydrate and high-fiber diet and education | decrease | fasting plasma glucose | male patients with nonalcoholic fatty liver disease | - | were lower | #20 |
low-carbohydrate and high-fiber diet and education | increase | serum high-density lipoprotein cholesterol | male patients with nonalcoholic fatty liver disease | - | was higher | #21 |
low-carbohydrate and high-fiber diet and education | decrease | body weight | patients with nonalcoholic fatty liver disease | - | can effectively reduce | #22 |
low-carbohydrate and high-fiber diet and education | decrease | body fat | patients with nonalcoholic fatty liver disease | - | can effectively reduce | #23 |
low-carbohydrate and high-fiber diet and education | increase | liver enzymes | patients with nonalcoholic fatty liver disease | - | improve | #24 |
low-carbohydrate and high-fiber diet and education | increase | blood glucose | patients with nonalcoholic fatty liver disease | - | improve | #25 |
low-carbohydrate and high-fiber diet and education | increase | blood lipid | patients with nonalcoholic fatty liver disease | - | improve | #26 |
low-carbohydrate and high-fiber diet and education | increase | uric acid | patients with nonalcoholic fatty liver disease | - | improve | #27 |
BACKGROUND AND OBJECTIVES: To study the effects of a low-carbohydrate and high-fiber diet and education on patients with nonalcoholic fatty liver disease. METHODS AND STUDY DESIGN: We randomly divided 44 patients with nonalcoholic fatty liver disease into two groups: low-carbohydrate and high-fiber diet and education (intervention group), and education alone (control group). Liver and kidney function, fasting plasma glucose, insulin resistance index, body composition, and controlled attenuation parameter were detected before and after the intervention. RESULTS: After 2 months, the body fat, body weight, abdominal circumference, and visceral fat area, fasting plasma glucose, insulin resistance index, and levels of serum alanine aminotransferase, aspartate transaminase, uric acid, and insulin of the intervention group were significantly lower than before (p<0.05). In the female intervention group, the insulin resistance index and levels of serum alanine aminotransferase, uric acid, triglyceride, fasting plasma glucose, and C-peptide were lower and the level of serum high-density lipoprotein cholesterol was higher than in the female control group (p<0.05). In the male intervention group, the levels of serum alanine aminotransferase, triglyceride, and fasting plasma glucose were lower and the level of serum high-density lipoprotein cholesterol was higher compared with the male control group (p<0.05). CONCLUSIONS: A low-carbohydrate and high-fiber diet and education can effectively reduce the body weight and body fat of patients with nonalcoholic fatty liver disease and improve metabolic indicators such as liver enzymes, blood glucose, blood lipid, and uric acid. Our female patients showed significantly better improvement in the indicators than our male patients.