Effect of a low-fat diet on serum triglyceride and cholesterol concentrations and lipoprotein profiles in Miniature Schnauzers with hypertriglyceridemia.
Study Goal
The researchers aimed to evaluate the effect of a commercially available low-fat diet on serum triglyceride and cholesterol concentrations and lipoprotein profiles in Miniature Schnauzers with hypertriglyceridemia.
Results Summary
The low-fat diet significantly reduced serum triglyceride and cholesterol concentrations and improved lipoprotein profiles in hypertriglyceridemic Miniature Schnauzers, with fewer dogs classified as hyperlipidemic after the dietary intervention.
Population
Miniature Schnauzers with and without hypertriglyceridemia.
Effective Dosage
Not specified (commercially available low-fat diet).
Duration
3 months.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
low-fat diet | decrease | serum triglyceride concentrations | Miniature Schnauzer with hypertriglyceridemia | median of sample 3 = 177 mg/dL; median of sample 4 = 168 mg/dL vs median of sample 1 = 480 mg/dL; median of sample 2 = 493 mg/dL | significantly lower | #1 |
low-fat diet | decrease | serum cholesterol concentrations | Miniature Schnauzer with hypertriglyceridemia | mean for sample 3 = 257 mg/dL; mean for sample 4 = 178 mg/dL vs mean for sample 1 = 381 mg/dL; mean for sample 2 = 380 mg/dL | significantly lower | #2 |
low-fat diet | decrease | classified as hyperlipidemic based on lipoprotein profile analysis | Miniature Schnauzer with hypertriglyceridemia | 7/16 (44%) vs 15/16 (94%); odds ratio = 19.3 | significantly fewer | #3 |
low-fat diet | decrease | serum triglyceride concentrations | Miniature Schnauzer with hypertriglyceridemia | - | effective in reducing | #4 |
low-fat diet | decrease | serum cholesterol concentrations | Miniature Schnauzer with hypertriglyceridemia | - | effective in reducing | #5 |
low-fat diet | decrease | lipoprotein profiles | Miniature Schnauzer with hypertriglyceridemia | - | correcting | #6 |
BACKGROUND: Hypertriglyceridemia is common in Miniature Schnauzer (MS). Dietary management of hypertriglyceridemia is important, but no studies are available. HYPOTHESIS/OBJECTIVES: To evaluate the effect of a commercially available low-fat diet on serum triglyceride and cholesterol concentrations and lipoprotein profiles in MS with hypertriglyceridemia. ANIMALS: Sixteen MS with hypertriglyceridemia and 28 MS without hypertriglyceridemia. METHODS: Prospective clinical trial. Four blood samples (1-2 months before and 1 day before diet change and 2 and 3 months after the dogs were fed the low-fat diet) were collected from the MS with hypertriglyceridemia. RESULTS: Serum triglyceride concentrations for the 2 samples after the diet change (median of sample 3 = 177 mg/dL; range, 48-498; median of sample 4 = 168 mg/dL; range, 77-745) were significantly lower than the 2 samples before the diet change (median of sample 1 = 480 mg/dL; range, 181-1320; median of sample 2 = 493 mg/dL; range, 114-1395; P < .001). Serum cholesterol concentrations for the 2 samples after the diet change (mean for sample 3 = 257 mg/dL, SD = 82.2; mean for sample 4 = 178 mg/dL, SD = 87.4) were also significantly lower than the 2 samples before the diet change (mean for sample 1 = 381 mg/dL, SD = 146.1; mean for sample 2 = 380 mg/dL, SD = 134.7; P < .001). Before the diet change, 15/16 (94%) of hyperlipidemic MS were classified as hyperlipidemic based on their lipoprotein profiles alone. After the diet change, significantly fewer MS (7/16; 44%; odds ratio = 19.3; 95% CI = 2.0-184.0; P = .006) were classified as hyperlipidemic based on lipoprotein profile analysis. CONCLUSIONS AND CLINICAL IMPORTANCE: The study diet was effective in reducing serum triglyceride and cholesterol concentrations and correcting lipoprotein profiles in MS with hypertriglyceridemia.