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Adjunctive bright light therapy for treating bipolar depression: A systematic review and meta-analysis of randomized controlled trials.

Brain and behavior
December 1, 2020
Hirofumi Hirakawa et al. (4 authors)
Journal ArticleMeta-AnalysisSystematic ReviewHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the adjunctive efficacy of bright light therapy (BLT) for treating bipolar depression in combination with pharmacological treatment, focusing on randomized controlled trials (RCTs).

Results Summary

The meta-analysis found that bright light therapy significantly reduced depression symptoms in patients with bipolar depression, with a risk ratio of 1.78 (95% CI 1.24-2.56, p = .002). The intervention group showed higher response and remission rates compared to the control group.

Population

Patients with bipolar depression (190 participants across 4 trials).

Effective Dosage

Not specified in the abstract.

Duration

Not specified in the abstract.

Interactions

None mentioned.

Extracted Claims (4)
InterventionDirectionEndpointPopulationDosageImpactClaim #
Bright light therapy (BLT)
decrease
bipolar disorder
-
-
was reported as an effective adjunctive treatment option
#1
augmentation treatment with light therapy
decrease
the severity of bipolar depression
-
-
significantly decreased
#2
Bright light therapy
decrease
depression symptoms
patients with bipolar depression
-
is an effective treatment for reducing
#3
Bright light therapy
increase
response rate and remission rate
participants with bipolar depression
1.78 (95% CI 1.24-2.56, p = .002)
showed risk ratios of
#4
Abstract

OBJECTIVES: Bright light therapy (BLT) was reported as an effective adjunctive treatment option for bipolar disorder. Previous meta-analytic study showed that augmentation treatment with light therapy significantly decreased the severity of bipolar depression. However, most of included studies were case-control studies and several of them focused on BLT that was provided in combination with sleep deprivation therapy. METHODS: In this meta-analysis, we used several electronic databases to search the studies and included only randomized controlled trial (RCT) studies to compare BLT with control experimental groups for treating bipolar depression with pharmacological treatment to clarify the adjunctive efficacy of BLT. We searched the databases of EMBASE, MEDLINE, Scopus, The Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature, and Clinicaltrials.gov for studies published in English until September 19, 2019. Two researchers conducted the literature screening, data extraction, and methodological quality assessment independently. The main outcome was the response rate and remission rate. We used the Review Manager 5.3 Software for the meta-analysis. RESULTS: Four trials with a total of 190 participants (intervention: 94, control: 96) with bipolar depression were evaluated to gauge the effects of light therapy. The meta-analysis showed risk ratios of 1.78 (95% CI 1.24-2.56, p = .002; I CONCLUSIONS: Bright light therapy is an effective treatment for reducing depression symptoms among patients with bipolar depression.

Medical Subject Headings (MeSH)
Bipolar DisorderHumansOdds RatioPhototherapyRandomized Controlled Trials as TopicTreatment Outcome
Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality80/10
Citation Metrics
Total Citations20
Citations/Year4.0
Relative Citation Ratio1.67
NIH Percentile68.8%
Research Impact Scores
APT Score0.75
Weight Score2.43
Normalized Score0.70
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