Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study.
Frontiers in physiology
January 1, 2020
Akram Imam et al. (14 authors)
Journal ArticleHuman Study
Extracted Claims (15)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Melatonin | neutral | circadian rhythms in physiology and sleep initiation | - | - | modulates | #1 |
Melatonin | increase | sleep quality | Patients with rare MTNR1B variants | - | improved | #2 |
Melatonin | increase | sleep duration | Patients with rare MTNR1B variants | - | improved | #3 |
Melatonin | increase | sleep efficiency | Patients with rare MTNR1B variants | - | improved | #4 |
Melatonin | increase | sleep latency | Patients with rare MTNR1B variants | - | improved | #5 |
Melatonin | increase | insulin sensitivity | Patients with rare MTNR1B variants | - | improved | #6 |
Melatonin | increase | glucose tolerance | Patients with rare MTNR1B variants | - | improved | #7 |
Melatonin | increase | beta-cell function | Patients with rare MTNR1B variants | - | improved | #8 |
Melatonin | increase | sleep quality | T2D MTNR1B variant carriers | - | improved | #9 |
Melatonin | increase | sleep duration | T2D MTNR1B variant carriers | - | improved | #10 |
Melatonin | increase | sleep efficiency | T2D MTNR1B variant carriers | - | improved | #11 |
Melatonin | increase | sleep latency | T2D MTNR1B variant carriers | - | improved | #12 |
Melatonin | increase | insulin sensitivity | T2D MTNR1B variant carriers | - | improved | #13 |
Melatonin | increase | glucose tolerance | T2D MTNR1B variant carriers | - | improved | #14 |
Melatonin | increase | beta-cell function | T2D MTNR1B variant carriers | - | improved | #15 |
Abstract
BACKGROUND: Melatonin modulates circadian rhythms in physiology and sleep initiation. Genetic variants of the MATERIALS AND METHODS: In this pilot study, 28 individuals [50% male; 46-82 years old; 50% with rare MT RESULTS: Patients with rare MT CONCLUSION: This pilot study suggests that compared to diabetic controls, T2D MT
Study Links
PubMed ID33162895
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