Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.
Study Goal
The researchers aimed to systematically review the effect of melatonin on sleep quality in adults with various diseases, as measured by the Pittsburgh Sleep Quality Index (PSQI).
Results Summary
Melatonin significantly improved sleep quality (WMD: -1.24; 95% CI -1.77, -0.71, p = 0.000), with positive effects observed in adults with respiratory diseases, metabolic disorders, and primary sleep disorders, but not in those with mental disorders, neurodegenerative diseases, or other conditions.
Population
Adults with various diseases, including respiratory, metabolic, primary sleep, mental, and neurodegenerative disorders.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin | decrease | sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) | adults with various diseases | WMD: -1.24; 95% CI -1.77, -0.71, p = 0.000 | had significant effect on | #1 |
exogenous melatonin | decrease | sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) | adult | - | has positive effects on | #2 |
exogenous melatonin | decrease | sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) | adults with respiratory diseases | - | has positive effects on | #3 |
exogenous melatonin | decrease | sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) | adults with metabolic disorders | - | has positive effects on | #4 |
exogenous melatonin | decrease | sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) | adults with primary sleep disorders | - | has positive effects on | #5 |
exogenous melatonin | no change | sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) | adults with mental disorders | - | has positive effects on | #6 |
exogenous melatonin | no change | sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) | adults with neurodegenerative diseases | - | has positive effects on | #7 |
exogenous melatonin | no change | sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) | adults with other diseases | - | has positive effects on | #8 |
BACKGROUND: The Present study was conducted to systematically review the effect of the melatonin on sleep quality. We summarized evidence from randomized clinical trials (RCTs) that investigated the effects of melatonin on sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) in adults with various diseases. METHODS: The literature searches of English publications in MEDLINE and EMBASE databases were performed up June 2020. Results were summarized as mean differences (MD) with 95% confidence intervals (CI) using random effects model (DerSimonian-Laird method). Heterogeneity among studies was evaluated by the Cochrane Q test and I-squared (I2). To determine the predefined sources of heterogeneity, subgroup analysis was performed. RESULTS: Of 2642 papers, 23 RCTs met inclusion criteria. Our results indicated that melatonin had significant effect on sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) (WMD: - 1.24; 95% CI - 1.77, - 0.71, p = 0.000). There was significant heterogeneity between studies (I CONCLUSION: We found that the treatment with exogenous melatonin has positive effects on sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) in adult. In adults with respiratory diseases, metabolic disorders, primary sleep disorders, not with mental disorders, neurodegenerative diseases and other diseases.