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Efficacy of dietary supplements on improving sleep quality: a systematic review and meta-analysis.

Postgraduate medical journal
April 1, 2022
Vicky Chan et al. (2 authors)
Journal ArticleMeta-AnalysisSystematic ReviewHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the efficacy of dietary supplements, including melatonin, in improving subjective sleep quality.

Results Summary

Melatonin supplementation significantly improved subjective sleep quality, though high heterogeneity and wide confidence intervals were observed.

Population

Not specified (general population inferred from abstract).

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (3)
InterventionDirectionEndpointPopulationDosageImpactClaim #
amino acids
increase
subjective sleep quality
-
MD -1.27, 95% CI -2.35 to -0.20
significantly improved
#1
vitamin D
increase
sleep quality
-
-
significantly beneficial to improve
#2
melatonin
increase
sleep quality
-
-
significantly beneficial to improve
#3
Abstract

PURPOSE: Different dietary supplements aimed at improving sleep quality are available on the market, but there has not been a comprehensive review to evaluate the efficacy of these dietary supplements on subjective sleep quality. We aimed to summarise up-to-date research evidence and to identify the types of dietary supplement that improve subjective sleep quality. METHODS: Multiple databases (Ovid Emcare, Ovid MEDLINE (R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and APA PsycInfo) were used for searching papers published until August 2020. The changes in sleep quality indices, intervention duration and sample size were extracted from every paper. To analyse the effect of dietary supplements on sleep quality, a random effects model with mean difference (MD) and 95% CI was adopted. The heterogeneity across studies was measured by I RESULTS: Thirty-one randomised controlled trials of dietary supplements were included. Subjective sleep quality was significantly improved by supplementation of amino acids (MD -1.27, 95% CI -2.35 to -0.20; I CONCLUSIONS: Amino acids, vitamin D and melatonin supplements were significantly beneficial to improve sleep quality. However, high heterogeneity and wide confidence levels were observed in vitamin D and melatonin. Further research on the effect of magnesium, zinc, resveratrol and nitrate supplementation on improving sleep quality is required.

Medical Subject Headings (MeSH)
Dietary SupplementsHumansSleep QualityVitamins
Study Links
Quality Scores
SafetyNot Assessed
Efficacy75/10
Quality85/10
Citation Metrics
Total Citations30
Citations/Year10.0
Relative Citation Ratio4.96
NIH Percentile92.9%
Research Impact Scores
APT Score0.95
Weight Score2.97
Normalized Score0.67
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