Long-term effect of a low-fat, high-carbohydrate diet on plasma lipids of patients affected by familial endogenous hypertriglyceridemia.
Study Goal
The researchers aimed to evaluate the effect of a low-fat, high-carbohydrate diet on plasma lipid levels in patients with familial endogenous hypertriglyceridemia.
Results Summary
The study found that the high-carbohydrate diet significantly reduced total plasma triglyceride and cholesterol levels, with notable decreases in VLDL cholesterol and increases in LDL and HDL cholesterol. The diet was deemed potentially useful for managing hypertriglyceridemia.
Population
10 patients with familial endogenous hypertriglyceridemia.
Effective Dosage
Approximately 60% of energy as carbohydrate (isocaloric diet).
Duration
12-week intervention period.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
low-fat, high carbohydrate (LFHC) diet | decrease | Total plasma triglyceride levels | 10 patients affected by familial endogenous hypertriglyceridemia | - | decreased significantly | #1 |
low-fat, high carbohydrate (LFHC) diet | decrease | Total plasma cholesterol levels | 10 patients affected by familial endogenous hypertriglyceridemia | - | decreased significantly | #2 |
low-fat, high carbohydrate (LFHC) diet | decrease | VLDL cholesterol | 10 patients affected by familial endogenous hypertriglyceridemia | - | decrease | #3 |
low-fat, high carbohydrate (LFHC) diet | increase | LDL cholesterol | 10 patients affected by familial endogenous hypertriglyceridemia | - | increased | #4 |
low-fat, high carbohydrate (LFHC) diet | increase | HDL cholesterol | 10 patients affected by familial endogenous hypertriglyceridemia | - | significant increase | #5 |
We evaluated the effect of a low-fat, high carbohydrate (LFHC) diet on plasma lipids in 10 patients affected by familial endogenous hypertriglyceridemia. All the patients studied underwent a base-line period of 4 wk, a 12-wk intervention period, and an 8-wk switch-back period. During the control periods patients consumed approximately 45% of energy as fat and approximately 40% as carbohydrate. During the intervention period they consumed an isocaloric diet containing approximately 25% of energy as fat and approximately 60% as carbohydrate. Total plasma triglyceride and cholesterol levels decreased significantly after 45 and 90 d of treatment (p less than 0.01). The reduction of plasma cholesterol was associated mostly with the decrease in VLDL cholesterol (p less than 0.01) while LDL cholesterol increased at days 45 and 90 of the LFHC diet (p less than 0.01). Finally, we observed a significant increase in HDL cholesterol both at days 45 and 90 of the LFHC diet (p less than 0.01). The LFHC diet we used may be an useful tool in the management of hypertriglyceridemia.