Panacea Index Logo

Command Palette

Search for a command to run...

The effects of bright light therapy on depression and sleep disturbances in patients with Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials.

Sleep medicine
July 1, 2021
Fabin Lin et al. (7 authors)
Journal ArticleMeta-AnalysisSystematic ReviewHuman Study
Extracted Claims (3)
InterventionDirectionEndpointPopulationDosageImpactClaim #
bright light therapy (BLT)
decrease
depression symptoms (BDI, GDS-30, HDRS and HADS)
patients with PD
0.34, 95% CI = 0.06-0.61
significantly improved
#1
bright light therapy (BLT)
decrease
Insomnia symptoms (SCOPA and ISI)
patients with PD
1.15, 95% CI = 0.71-1.60
significantly improved
#2
control light group
no change
depression or insomnia symptoms
PD patients
-
no difference was observed
#3
Abstract

BACKGROUND: Depression and sleep disturbance are well-recognized non-motor features in patients with Parkinson's disease (PD). This meta-analysis aimed to explore the potential role of bright light therapy (BLT) in depression and sleep disturbances in Parkinson's Disease (PD). METHODS: Four databases were independently searched by two reviewers: PubMed, Cochrane, Web of Science and Embase until February 2021. We evaluated the following depression related scales: Beck's Depression Inventory (BDI); the Geriatric Depression Rating Scale, 30-item (GDS-30); the Hamilton Depression Rating Scale (HDRS); the Hospital Anxiety and Depression Scale (HADS); the Epworth sleepiness scale (ESS); the Fatigue Severity Scale (FSS); the Pittsburgh sleep quality index (PSQI); the Parkinson's disease sleep scale (PDSS); Scales for Outcomes in Parkinson's disease Sleep Scale (SCOPA) and the Insomnia severity index (ISI) to access the effects of bright light therapy on depression and sleep disturbances in patients with PD. Effect size (standardized mean deviation [SMD] and 95% confidence interval [CI]) were used to analyze the continuous results data of intervention group and control light group. Data from five randomized, controlled trials totaling 173 patients with PD was included. RESULTS: BLT significantly improved depression symptoms (BDI, GDS-30, HDRS and HADS) of PD patients (0.34, 95% CI = 0.06-0.61). Insomnia symptoms (SCOPA and ISI) for patients with PD were significantly improved by BLT as well (1.15, 95% CI = 0.71-1.60). Whereas, no difference was observed in the control light group in improving the depression or insomnia symptoms of PD patients. CONCLUSION: BLT is an effective intervention for improving depressive symptoms and sleep disturbances in patients with PD.

Medical Subject Headings (MeSH)
AgedDepressionHumansParkinson DiseasePhototherapyRandomized Controlled Trials as TopicSleepSleep Wake Disorders
Study Links
Citation Metrics
Total Citations29
Citations/Year7.3
Relative Citation Ratio2.68
NIH Percentile82.4%
Research Impact Scores
APT Score0.75
Related Supplements