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Vitamin D in critical care: where are we now and what is next?

Current opinion in critical care
January 1, 1970
Karin Amrein et al. (4 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

To summarize recent evidence on the role of vitamin D deficiency in critically ill patients and its potential role in COVID-19.

Results Summary

Vitamin D deficiency is a strong predictor of worse outcomes in critically ill patients and COVID-19. Supplementation may reduce respiratory infections, asthma exacerbations, and mortality risk in non-critically ill patients, but its role in acute settings remains unclear.

Population

Critically ill patients, COVID-19 patients, and elderly ICU survivors.

Effective Dosage

600-800 IU of native vitamin D3 (recommended standard dose for the healthy population).

Duration

Not specified.

Interactions

None mentioned.

Extracted Claims (6)
InterventionDirectionEndpointPopulationDosageImpactClaim #
vitamin D supplementation
decrease
respiratory tract infections
noncritically ill patients
-
has been shown to reduce
#1
vitamin D supplementation
decrease
asthma exacerbations
noncritically ill patients
-
has been shown to reduce
#2
vitamin D supplementation
decrease
mortality risk
noncritically ill patients
-
has been shown to reduce
#3
vitamin D
neutral
outcomes
critically ill patients
-
is a strong predictor for worse outcomes
#4
vitamin D
neutral
outcomes
COVID-19 patients
-
is a strong predictor for worse outcomes
#5
vitamin D
neutral
bone health
-
-
has a role
#6
Abstract

PURPOSE OF REVIEW: To summarize the recent evidence on the role of vitamin D deficiency in critically ill patients and emerging data claiming a role of vitamin D in COVID-19. RECENT FINDINGS: Vitamin D is a strong predictor for worse outcomes in critically ill patients, and as well in COVID-19. The vitamin D content in typical nutrition regimes is lower than what is recommended for the general population. Although its supplementation has been shown to reduce respiratory tract infections, asthma exacerbations and mortality risk in noncritically ill patients, its role in the acute setting is not yet clear. Several small intervention trials have shown interesting results in COVID-19, and larger studies are ongoing. SUMMARY: Although research on this topic is still ongoing, it appears reasonable to recommend at least the standard vitamin dose for the healthy population (600--800 IU of native vitamin D3). Many questions remain on the actual role, the best metabolite, regime, and so forth. However, the role for vitamin D in bone health is clear. Elderly ICU survivors have a high risk for osteoporosis/fractures, so at least in this population, an optimal vitamin D status should be targeted.

Medical Subject Headings (MeSH)
AgedCOVID-19Critical CareDietary SupplementsHumansSARS-CoV-2Vitamin DVitamins
Study Links
Quality Scores
Safety85
Efficacy70/10
Quality75/10
Citation Metrics
Total Citations8
Citations/Year2.0
Relative Citation Ratio0.76
NIH Percentile40.1%
Research Impact Scores
APT Score0.50
Weight Score0.78
Normalized Score0.77
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