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Alzheimer's disease and sleep disorders: Insights into the possible disease connections and the potential therapeutic targets.

Asian journal of psychiatry
February 1, 2022
Vaibhav S Marde et al. (10 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to discuss chamomile as a plant-based nutraceutical with potential effects on sleep disorders, focusing on its hypothesized mechanism of action.

Results Summary

The abstract mentions chamomile as one of the recognized nutraceuticals for sleep disorders but does not provide specific findings on its efficacy or mechanisms.

Population

Patients with Alzheimer's disease and comorbid sleep disorders.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (9)
InterventionDirectionEndpointPopulationDosageImpactClaim #
Peter Hauri rules
neutral
regulation of sleep-wake cycles
-
-
play a key role
#1
sleep education program
neutral
regulation of sleep-wake cycles
-
-
play a key role
#2
light therapy
neutral
regulation of sleep-wake cycles
-
-
play a key role
#3
Pharmacological therapy
decrease
sleep destruction
patients with Alzheimer's disease
-
may be useful in treating
#4
caffeine
neutral
sleep disorders
-
-
hypothesized impact on
#5
chamomile
neutral
sleep disorders
-
-
hypothesized impact on
#6
cherries
neutral
sleep disorders
-
-
hypothesized impact on
#7
L-tryptophan
neutral
sleep disorders
-
-
hypothesized impact on
#8
valerian
neutral
sleep disorders
-
-
hypothesized impact on
#9
Abstract

One of the comorbid conditions in an individual with Alzheimer's disease is a sleep disorder. Clinical features of sleep disorders involve various sleep disturbances such as Obstructive Sleep Apnea (OSAS), Excessive Daytime Sleepiness (EDS), Rapid Eye Movement (REM), Breathing Disorders, Periodic limb movements in sleep (PLMS), etc. The primary tools used for the identification of such disturbances are Polysomnography (PSG) and Wrist actigraphy. This review will highlight and explains the different approaches used in the treatment of sleep disorders. Non-pharmacological treatments include Peter Hauri rules, sleep education program, and light therapy which play a key role in the regulation of sleep-wake cycles. Pharmacological therapy described in this article may be useful in treating sleep destruction in patients with Alzheimer's disease. Along with the Non-pharmacological and pharmacological treatment, here we discuss five commonly recognized plant-based nutraceuticals with hypothesized impact on sleep disorders: caffeine, chamomile, cherries, L-tryptophan, and valerian by the proper emphasis on the known mechanism of their action.

Medical Subject Headings (MeSH)
Alzheimer DiseaseDisorders of Excessive SomnolenceHumansPolysomnographySleepSleep Wake Disorders
Study Links
Quality Scores
SafetyNot Assessed
Efficacy50/10
Quality60/10
Citation Metrics
Total Citations20
Citations/Year6.7
Relative Citation Ratio2.36
NIH Percentile79.2%
Research Impact Scores
APT Score0.50
Weight Score2.35
Normalized Score0.52
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