Alzheimer's disease and sleep disorders: Insights into the possible disease connections and the potential therapeutic targets.
Study Goal
The researchers aimed to discuss chamomile as a plant-based nutraceutical with potential effects on sleep disorders, focusing on its hypothesized mechanism of action.
Results Summary
The abstract mentions chamomile as one of the recognized nutraceuticals for sleep disorders but does not provide specific findings on its efficacy or mechanisms.
Population
Patients with Alzheimer's disease and comorbid sleep disorders.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Peter Hauri rules | neutral | regulation of sleep-wake cycles | - | - | play a key role | #1 |
sleep education program | neutral | regulation of sleep-wake cycles | - | - | play a key role | #2 |
light therapy | neutral | regulation of sleep-wake cycles | - | - | play a key role | #3 |
Pharmacological therapy | decrease | sleep destruction | patients with Alzheimer's disease | - | may be useful in treating | #4 |
caffeine | neutral | sleep disorders | - | - | hypothesized impact on | #5 |
chamomile | neutral | sleep disorders | - | - | hypothesized impact on | #6 |
cherries | neutral | sleep disorders | - | - | hypothesized impact on | #7 |
L-tryptophan | neutral | sleep disorders | - | - | hypothesized impact on | #8 |
valerian | neutral | sleep disorders | - | - | hypothesized impact on | #9 |
One of the comorbid conditions in an individual with Alzheimer's disease is a sleep disorder. Clinical features of sleep disorders involve various sleep disturbances such as Obstructive Sleep Apnea (OSAS), Excessive Daytime Sleepiness (EDS), Rapid Eye Movement (REM), Breathing Disorders, Periodic limb movements in sleep (PLMS), etc. The primary tools used for the identification of such disturbances are Polysomnography (PSG) and Wrist actigraphy. This review will highlight and explains the different approaches used in the treatment of sleep disorders. Non-pharmacological treatments include Peter Hauri rules, sleep education program, and light therapy which play a key role in the regulation of sleep-wake cycles. Pharmacological therapy described in this article may be useful in treating sleep destruction in patients with Alzheimer's disease. Along with the Non-pharmacological and pharmacological treatment, here we discuss five commonly recognized plant-based nutraceuticals with hypothesized impact on sleep disorders: caffeine, chamomile, cherries, L-tryptophan, and valerian by the proper emphasis on the known mechanism of their action.