Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Disease: A Meta-Analysis.
Study Goal
The researchers aimed to evaluate the efficacy and safety of various light therapy (LT) measures in improving motor and non-motor symptoms in patients with idiopathic Parkinson's disease (PD).
Results Summary
The meta-analysis found that LT significantly improved motor function, depression, and sleep disturbance-related scores in PD patients compared to dim-red light controls. The results provide strong evidence for LT's efficacy in PD symptom management.
Population
Patients with idiopathic Parkinson's disease
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Light therapy (LT) | decrease | motor function | patients with idiopathic PD | MD=-4.68, 95% Cl -8.25 to -1.12, P=0.01 | had significantly better scores | #1 |
Light therapy (LT) | decrease | depression | patients with idiopathic PD | SMD=-0.27, 95% Cl -0.52 to -0.02, P=0.04 | showed significant optimization | #2 |
Light therapy (LT) | increase | sleep disturbance-related scores | patients with idiopathic PD | MD=3.45, 95% Cl 0.12 to 6.78, P=0.04 | showed significant optimization | #3 |
Light therapy (LT) | increase | motor and non-motor function | PD patients | - | has significant efficacy | #4 |
BACKGROUND Non-visual effects of the retina have been increasingly confirmed in developing Parkinson disease (PD). Light therapy (LT) has been proven to be an effective non-pharmacotherapy for improving the prognosis of PD, but the pathway of action is unclear, and there is a lack of a unified and standardized LT regimen. We aimed to evaluate the efficacy and safety of various LT measures in improving motor and non-motor symptoms in patients with idiopathic PD via a meta-analysis. MATERIAL AND METHODS CENTRAL, EMBASE, CINAHL, PEDro, and PubMed were searched for randomized controlled trials (RCTs) investigating the efficacy of LT for PD. Cochrane's Risk of bias tool and the GRADE approach were used to assess evidence quality. A meta-analysis and subgroup analyses evaluated the differences in efficacy produced by the different LT protocols. Trial sequential analysis (TSA) verified the analyses outcome and quantified the statistical relevance of the data.[color=#0e101a] [/color] RESULTS Patients receiving LT had significantly better scores for motor function (MD=-4.68, 95% Cl -8.25 to -1.12, P=0.01) compared with the control group exposed to dim-red light. In addition, in terms of non-motor symptoms, depression (SMD=-0.27, 95% Cl -0.52 to -0.02, P=0.04) and sleep disturbance-related scores (MD=3.45, 95% Cl 0.12 to 6.78, P=0.04) similarly showed significant optimization after receiving LT. CONCLUSIONS The results of this meta-analysis show strong evidence that LT has significant efficacy on motor and non-motor function in PD patients.