Vitamin D
Study Goal
The researchers aimed to determine whether high-dose vitamin D supplementation could improve bone health in children living with HIV in sub-Saharan Africa.
Results Summary
The abstract does not provide specific results regarding the effects of vitamin D supplementation, as it describes the trial design and objectives rather than outcomes.
Population
Children living with HIV in sub-Saharan Africa.
Effective Dosage
Weekly high-dose vitamin D (specific amount not mentioned).
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
antiretroviral therapy | increase | chronic complications | children living with HIV | - | associated with | #1 |
antiretroviral therapy | increase | growth failure | children living with HIV | - | associated with | #2 |
antiretroviral therapy | increase | stunting | children living with HIV | - | associated with | #3 |
antiretroviral therapy | increase | delayed puberty | children living with HIV | - | associated with | #4 |
Vitamin D deficiency | decrease | bone health | children living with HIV in sub-Saharan Africa | - | has a further adverse impact on | #5 |
weekly high-dose vitamin D supplementation | increase | bone mineral density | children living with HIV | - | aims to establish whether | #6 |
weekly high-dose vitamin D supplementation | increase | bone mineral content | children living with HIV | - | aims to establish whether | #7 |
weekly high-dose vitamin D supplementation | increase | bone area | children living with HIV | - | aims to establish whether | #8 |
weekly high-dose vitamin D supplementation | increase | linear growth | children living with HIV | - | aims to establish whether | #9 |
weekly high-dose vitamin D supplementation | increase | immune function | children living with HIV | - | aims to establish whether | #10 |
weekly high-dose vitamin D supplementation | increase | cardiometabolic health | children living with HIV | - | aims to establish whether | #11 |
weekly high-dose vitamin D supplementation | increase | physical function | children living with HIV | - | aims to establish whether | #12 |
weekly high-dose vitamin D supplementation | increase | quality of life | children living with HIV | - | aims to establish whether | #13 |
BACKGROUND: Of the 2 million children living with HIV globally, 90% live in sub-Saharan Africa. Despite antiretroviral therapy, longstanding HIV infection is associated with several chronic complications in children including growth failure, particularly stunting and delayed puberty. Vitamin D deficiency, which is highly prevalent among children living with HIV in sub-Saharan Africa, has a further adverse impact on bone health. This trial aims to establish whether supplementation with vitamin D METHODS/DESIGN: We will conduct an individually randomised, double-blinded, placebo-controlled trial of weekly high-dose vitamin D DISCUSSION: This is the largest trial to date of vitamin D supplementation in children living with HIV. Intervening to address deficits in bone accrual in childhood is critical for optimising adolescent and early adult bone health and prevention of later adult osteoporotic fractures. Trial results will draw attention to the need to screen for and treat long-term comorbidities in children living with HIV in resource-limited settings. TRIAL REGISTRATION: Pan African Clinical Trials Registry PACTR20200989766029 . Registered on 3 September 2020.