A low glycemic index, energy-restricted diet but not Lactobacillus rhamnosus supplementation changes fecal short-chain fatty acid and serum lipid concentrations in women with overweight or obesity and polycystic ovary syndrome.
Study Goal
The researchers aimed to determine if changes in fecal SCFA content due to an energy-restricted diet and probiotic supplementation affected the abundance of Akkermansia muciniphila and other gut bacteria in overweight and obese women with PCOS.
Results Summary
The study found that an energy-restricted diet improved lipid profiles and reduced body weight, but probiotic supplementation (including Lactobacillus rhamnosus) did not significantly affect the abundance of Akkermansia muciniphila or other selected gut bacteria.
Population
Overweight and obese women with PCOS (mean age 28.8 ± 4.8 years).
Effective Dosage
12 × 10^9 CFU/day of Lactobacillus rhamnosus.
Duration
20 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
energy-restricted diet | decrease | body weight | overweight and obese women with PCOS | - | significantly reduced | #1 |
energy-restricted diet | decrease | BMI | overweight and obese women with PCOS | - | significantly reduced | #2 |
energy-restricted diet | decrease | fat mass | overweight and obese women with PCOS | - | significantly reduced | #3 |
energy-restricted diet | decrease | acetic acid | overweight and obese women with PCOS | - | significantly reduced | #4 |
energy-restricted diet | decrease | butyric acid | overweight and obese women with PCOS | - | significantly reduced | #5 |
energy-restricted diet | increase | lipid profile | overweight and obese women with PCOS | - | improved | #6 |
energy-restricted diet | decrease | total cholesterol | overweight and obese women with PCOS | - | improved | #7 |
energy-restricted diet | decrease | low-density lipoprotein cholesterol | overweight and obese women with PCOS | - | improved | #8 |
energy-restricted diet | decrease | triglycerides | overweight and obese women with PCOS | - | improved | #9 |
energy-restricted diet | increase | molar ratio of SCFA | overweight and obese women with PCOS | towards the correct ratio | observed changes in | #10 |
Lactobacillus rhamnosus supplementation | no change | selected gut bacteria abundance | overweight and obese women with PCOS | - | has no additional beneficial effects on | #11 |
Lactobacillus rhamnosus supplementation | no change | SCFA levels | overweight and obese women with PCOS | - | has no additional beneficial effects on | #12 |
Lactobacillus rhamnosus supplementation | no change | lipid profile | overweight and obese women with PCOS | - | has no additional beneficial effects on | #13 |
OBJECTIVE: To evaluate if changes in fecal short-chain fatty acids (SCFA) content with an energy-restricted diet and with/without 12 × 109 CFU/day of Lactobacillus rhamnosus supplementation affect the abundance of selected gut bacteria and lipid profile in overweight and obese women with PCOS. PATIENTS AND METHODS: This randomized controlled trial involved 40 overweight and obese women with a mean age of 28.8 ± 4.8 years diagnosed with PCOS. The subjects were randomly assigned to an energy-restricted diet group (D group; n = 21) or energy-restricted diet + Lactobacillus rhamnosus supplementation group (DP group; n=19). SCFA, selected gut bacteria (Akkermansia muciniphila, Bifidobacterium longum, and Faecalibacterium prausnitzii) abundance, lipid profile and anthropometric parameters were evaluated at baseline and after twenty weeks of intervention. RESULTS: The energy-restricted diet significantly reduced body weight, BMI, fat mass, acetic and butyric acids, and improved the lipid profile (total cholesterol, low-density lipoprotein cholesterol, and triglycerides) of both groups. Changes in the molar ratio of SCFA towards the correct ratio were also observed. All the results were independent of Lactobacillus rhamnosus supplementation, with no significant differences between the two groups. CONCLUSIONS: Twenty weeks of probiotic supplementation has no additional beneficial effects on selected gut bacteria abundance, SCFA levels, or lipid profile beyond the effect of an energy-restricted diet in overweight and obese women with PCOS.