L-Carnitine effect on induced hyperlipidemia on premature rats: fertility profile.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
1.5% cholesterol with diet | increase | body weight | premature male rats (CFG1) | - | significant increase | #1 |
1.5% cholesterol with diet | increase | serum cholesterol | premature male rats (CFG1) | - | significant increase | #2 |
1.5% cholesterol with diet | increase | serum triglyceride | premature male rats (CFG1) | - | significant increase | #3 |
L-Carnitine (CAR) 150 mg/kg body weight | increase | sperms count | premature male rats (CFG2) | - | significant increase | #4 |
L-Carnitine (CAR) 150 mg/kg body weight | increase | sperms live percentage | premature male rats (CFG2) | - | significant increase | #5 |
L-Carnitine (CAR) 150 mg/kg body weight | decrease | sperms abnormalities percentage | premature male rats (CFG2) | - | significant decrease | #6 |
1.5% cholesterol with diet | decrease | serum testosterone levels | premature male rats (CFG1) | - | significant decrease | #7 |
L-Carnitine (CAR) | neutral | parameters of sperms | hypercholesterolemic premature rats | - | maintain | #8 |
L-Carnitine (CAR) | increase | fertilizing ability | subfertile rats that may occur due to hyperlipidemia | - | enhance | #9 |
This study was designed to investigate the effect of hypercholesterolemia on the reproductive performance of premature male rats and to evaluate the influence of L-Carnitine (CAR) in maintaining their fertility. Sixty rats were divided randomly into three groups. Control group (CG n=20 rats), cholesterol feeding group 1 (CFG1 n=20 rats) fed 1.5% cholesterol with diet for one month, and cholesterol feeding group 2 (CFG2 n=20 rats) fed 1.5% cholesterol with diet + CAR 150 mg/kg body weight (B.W.) given by water for one month. Results showed a significant increase in body weight of CFG1 compared with CG and CFG2. The lipid profile of CFG1 after one month of feeding cholesterol showed a significant increase in serum cholesterol and triglyceride compared with CG and with the group that watered by CAR and CFG2. Results of sperms parameters in CGF2 showed a significant increase in sperms count with sperms live percentage and a significant decrease in sperms abnormalities percentage compared with CGF1 and CG. The hormonal profile showed a significant decrease in serum testosterone levels in rats from CFG1 compared with CFG2 and CG. In conclusion, CAR is a powerful antioxidant that can maintain the parameters of sperms of hypercholesterolemic premature rats, which may enhance the fertilizing ability of subfertile rats that may occur due to hyperlipidemia.