The Role of
Oxidative medicine and cellular longevity
January 1, 2022
Ting Gao et al. (5 authors)
Journal ArticleAnimal Study
Extracted Claims (4)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin | decrease | sleep deprivation-caused oxidative stress-mediated gut microbiota disorder and colitis | - | - | effectively ameliorated | #1 |
melatonin | decrease | colitis | - | - | improving | #2 |
sleep deprivation | increase | colitis | mouse model | - | induced | #3 |
melatonin | neutral | MT2 | - | - | mediated | #4 |
Abstract
BACKGROUND: Our previous studies demonstrated that melatonin could effectively ameliorate sleep deprivation- (SD-) caused oxidative stress-mediated gut microbiota disorder and colitis. The research further clarified the mechanism of melatonin in improving colitis from the perspective of the interaction between METHODS: A seventy-two hours SD mouse model with or without melatonin intervention and fecal microbiota transplantation (FMT) to explore the vital position of RESULTS: Our study showed that SD induced colitis, with upregulation of CONCLUSIONS: Our results demonstrated that melatonin-mediated MT2 inhibits
Medical Subject Headings (MeSH)
AeromonasAnimalsCell CommunicationColitisGlycogen Synthase Kinase 3 betaGoblet CellsMelatoninMiceSleep Deprivation
Study Links
PubMed ID35355860
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