Can low-carbohydrate diets be recommended for reducing cardiovascular risk?
Study Goal
The researchers aimed to evaluate the rationale for using carbohydrate restriction to improve cardiovascular health, particularly in individuals with type 2 diabetes mellitus (T2DM) or metabolic syndrome.
Results Summary
The study found that carbohydrate restriction effectively improves or reverses biomarkers of cardiovascular health, including glycemia and atherogenic dyslipidemia, though it may increase serum LDL-C in some individuals. The benefits outweigh the potential adverse effects of elevated LDL-C.
Population
Individuals with T2DM, metabolic syndrome, or related co-morbidities.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
carbohydrate restriction | decrease | underlying risk factors | individuals with T2DM or metabolic syndrome | - | improves or reverses | #1 |
carbohydrate restriction | decrease | atherogenic dyslipidemia | - | - | favorably impacting | #2 |
low-carbohydrate diets | decrease | glycemia and cardiovascular risk | - | - | endorsed for improving | #3 |
low-carbohydrate diet | increase | serum low-density lipoprotein cholesterol (LDL-C) | a proportion of individuals | - | increase in | #4 |
carbohydrate restriction | increase | cardiovascular health | - | - | improve | #5 |
carbohydrate restriction | decrease | T2DM and insulin resistance | - | - | favorably impacting | #6 |
carbohydrate restriction | decrease | CVD risk | individuals with T2DM or metabolic syndrome | - | reduce | #7 |
PURPOSE OF REVIEW: This review provides a rationale for implementing carbohydrate restriction as a dietary therapy to improve biomarkers of cardiovascular health and suggests that this will require a paradigm shift away from what is currently promulgated as a 'heart-healthy' diet. RECENT FINDINGS: Type 2 diabetes mellitus (T2DM), metabolic syndrome, and related co-morbidities are major risk factors for cardiovascular disease (CVD). Ideally, then, a diet intended to support cardiovascular health should be one that improves or reverses these underlying risk factors. Carbohydrate restriction is effective for this purpose as well as for favorably impacting atherogenic dyslipidemia. Recent consensus reports from select national organizations have endorsed low-carbohydrate diets for improving glycemia and cardiovascular risk. Reluctance among public health organizations and some clinicians to more widely promote this therapeutic nutritional approach is driven primarily by the increase in serum low-density lipoprotein cholesterol (LDL-C) observed in a proportion of individuals who adopt a low-carbohydrate diet. Here we explore the rationale for using carbohydrate restriction to improve cardiovascular health by way of favorably impacting T2DM and insulin resistance, and why this salutary effect outweighs the potential adverse effects of an increase in serum LDL-C. SUMMARY: Carbohydrate restriction is a logical foundation for a dietary intervention intended to reduce CVD risk, particularly among individuals with T2DM or metabolic syndrome.