Panacea Index Logo

Command Palette

Search for a command to run...

Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults.

The New England journal of medicine
January 1, 1970
Meryl S LeBoff et al. (13 authors)
Journal ArticleRandomized Controlled TrialHuman StudyClinical
Study Details

Study Goal

The researchers aimed to determine whether supplemental vitamin D prevents fractures in the general population.

Results Summary

The study confirmed 1991 incident fractures in 1551 participants over a median follow-up of 5.3 years, but the abstract does not clearly state whether vitamin D supplementation significantly reduced fracture risk.

Population

25,871 participants (50.6% women, 20.2% Black).

Effective Dosage

Not specified in the abstract.

Duration

Median follow-up of 5.3 years.

Interactions

None mentioned.

Extracted Claims (3)
InterventionDirectionEndpointPopulationDosageImpactClaim #
Vitamin D supplements
neutral
bone health
the general population
-
are widely recommended
#1
Vitamin D supplements
no change
fractures
-
inconsistent
prevent fractures
#2
supplemental vitamin D
neutral
incident fractures
25,871 participants (50.6% women [13,085 of 25,871] and 20.2% Black [5106 of 25,304])
1991
-
#3
Abstract

BACKGROUND: Vitamin D supplements are widely recommended for bone health in the general population, but data on whether they prevent fractures have been inconsistent. METHODS: In an ancillary study of the Vitamin D and Omega-3 Trial (VITAL), we tested whether supplemental vitamin D RESULTS: Among 25,871 participants (50.6% women [13,085 of 25,871] and 20.2% Black [5106 of 25,304]), we confirmed 1991 incident fractures in 1551 participants over a median follow-up of 5.3 years. Supplemental vitamin D CONCLUSIONS: Vitamin D

Medical Subject Headings (MeSH)
AgedCholecalciferolDietary SupplementsDouble-Blind MethodFatty Acids, Omega-3FemaleFractures, BoneHip FracturesHumansMaleMiddle AgedOsteoporosisVitamin D Deficiency
Study Links
Quality Scores
SafetyNot Assessed
Efficacy50/10
Quality85/10
Citation Metrics
Total Citations167
Citations/Year55.7
Relative Citation Ratio24.39
NIH Percentile99.6%
Research Impact Scores
APT Score0.95
Weight Score2.10
Normalized Score0.57
Related Supplements
Supplemental Vitamin D and Incident Fractures in Midlife and... | Panacea Index