Therapeutic effects of melatonin on endometriosis, targeting molecular pathways: Current knowledge and future perspective.
Study Goal
The researchers aimed to review the current knowledge on melatonin's potential benefits in treating endometriosis, focusing on its antioxidant, anti-inflammatory, and anti-proliferative properties.
Results Summary
Melatonin shows promise in limiting endometriosis through multiple pathways, including antiestrogenic, antioxidant, and anti-inflammatory effects, as well as improving sleep quality and reducing symptoms. However, most data comes from experimental studies, and more clinical trials are needed.
Population
Women with endometriosis.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin | decrease | endometriosis | - | - | performances as a beneficial agent to limit | #1 |
melatonin | decrease | endometriosis | - | - | antiestrogenic, antioxidant, anti-inflammatory, and anti-apoptosis effects | #2 |
melatonin | decrease | E2-induced endometriotic tissue | - | - | reducing the growth of | #3 |
melatonin | increase | sleep quality | - | - | can favor | #4 |
melatonin | decrease | the unwanted signs | the patients | - | decrease | #5 |
Endometriosis, the very serious disease in women creates a huge financial burden worldwide, which is comparable to diabetes mellitus. In addition to the typical pelvic pain, endometriosis is related to low life quality and decreased work efficiency; clinical consequences include mood complaints, metabolic impairments, inflammation, immunologic problems, and elevated malignancy risks. Several risk factors are correlated with endometriosis including elevated oxidative and nitrosative stress, long-lasting inflammation, raised immune tolerance, as well as autoimmunity. Melatonin is a natural molecule present throughout both the plant and animal kingdoms. It has numerous functions as an antioxidant and anti-inflammatory agent. Due to the anti-proliferative, antioxidant, anti-inflammatory, and anti-invasive features of melatonin, it performances as a beneficial agent to limit endometriosis; this involves several pathways including antiestrogenic, antioxidant, anti-inflammatory, and anti-apoptosis effects, as well as reducing the growth of E2-induced endometriotic tissue. Moreover, melatonin can favor sleep quality and decrease the unwanted signs in the patients. However, most of the data on melatonin accured from experimental works and additional clinical trials are needed. This review summarizes what is currently known regarding the influence of melatonin on endometriosis. AVAILABILITY OF DATA AND MATERIAL: Not applicable.