Effects of phytosterol supplementation on lipid profiles in patients with hypercholesterolemia: a systematic review and meta-analysis of randomized controlled trials.
Study Goal
The researchers aimed to evaluate the effects of phytosterols on lipid profiles in patients with hypercholesterolemia through a systematic review and meta-analysis of randomized controlled trials.
Results Summary
The study found that phytosterols significantly reduced total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in patients with hypercholesterolemia, with statistically significant mean differences.
Population
Patients with hypercholesterolemia
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Phytosterols (PSs) | increase | blood lipids | patients with hypercholesterolemia | - | improve | #1 |
a diet containing a certain dose of plant sterol | decrease | total cholesterol (TC) | patients with hypercholesterolemia | Weight Mean Difference (WMD) [95% CI] = -0.37 [-0.41, -0.34] | significantly reduced | #2 |
a diet containing a certain dose of plant sterol | decrease | low density lipoprotein cholesterol (LDL-C) | patients with hypercholesterolemia | - | significantly reduced | #3 |
Phytosterols (PSs) have been reported to improve blood lipids in patients with hypercholesterolemia for many years. However, meta-analyses of the effects of phytosterols on lipid profiles are limited and incomplete. A systematic search of randomized controlled trials (RCTs) published in PubMed, Embase, Cochrane Library, and Web of Science from inception to March 2022 was conducted according to the 2020 preferred reporting items of the guidelines for systematic reviews and meta-analysis (PRISMA) statement. These included studies of people with hypercholesterolemia, comparing foods or preparations containing PSs with controls. Mean differences with 95% confidence intervals were used to estimate continuous outcomes for individual studies. The results showed that in patients with hypercholesterolemia, taking a diet containing a certain dose of plant sterol significantly reduced total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) (TC: Weight Mean Difference (WMD) [95% CI] = -0.37 [-0.41, -0.34],