Vitamin D and Respiratory Diseases : Based on 11th Dr. I. C. Verma Excellence in Research Award for Young Pediatricians Delivered as Oration on 15th Oct. 2023.
Study Goal
The researchers aimed to explore the role of Vitamin D in respiratory health, its association with respiratory diseases, and its potential as a preventive and therapeutic strategy.
Results Summary
Observational studies linked Vitamin D deficiency to respiratory diseases like asthma and pneumonia, but experimental studies did not show encouraging results. The review discusses Vitamin D's synthesis, metabolism, deficiency prevalence in children, and therapeutic trials in childhood respiratory diseases.
Population
Children (specifically regarding deficiency prevalence and respiratory diseases).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D | neutral | bone health and calcium metabolism | - | - | has been appreciated beyond | #1 |
Vitamin D | neutral | respiratory health | - | - | has importance in | #2 |
Vitamin D | neutral | respiratory diseases | - | - | could have a significant role in the pathogenesis of | #3 |
Vitamin D | neutral | respiratory diseases | - | - | may represent a novel preventive and therapeutic strategy for | #4 |
Vitamin D deficiency | neutral | respiratory diseases | - | - | established association with | #5 |
Vitamin D | no change | - | - | - | not shown encouraging results | #6 |
The significance of Vitamin D has been appreciated beyond bone health and calcium metabolism. The importance of Vitamin D in respiratory health has been recognized due to its immunomodulatory and anti-microbial properties. The hypothesis is that Vitamin D could have a significant role in the pathogenesis of respiratory diseases and may represent a novel preventive and therapeutic strategy. Furthermore, enumerable observational studies established the association of Vitamin D deficiency with respiratory diseases such as asthma, bronchiolitis, pneumonia, tuberculosis, etc. However, experimental studies have not shown the encouraging results. This brief review will summarize and discuss the synthesis and metabolism of Vitamin D, the prevalence of Vitamin D deficiency in children, its role in the pathogenesis of various childhood respiratory diseases, and an overview of the therapeutic trials assessing the role of Vitamin D supplementation in childhood respiratory diseases.