Update: Vitamin D
Study Goal
The researchers aimed to determine whether weekly high-dose vitamin D supplementation improves bone health in children living with HIV in sub-Saharan Africa.
Results Summary
The abstract does not provide specific results, as data analysis is ongoing. The study is the largest trial to date on vitamin D supplementation in children with HIV, focusing on bone health and long-term fracture prevention.
Population
Children living with HIV in sub-Saharan Africa, particularly those with growth failure, stunting, and delayed puberty.
Effective Dosage
Weekly high-dose vitamin D (exact dosage not specified).
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
antiretroviral therapy | neutral | chronic complications | children living with HIV | - | associated with | #1 |
longstanding HIV infection | neutral | growth failure | children | - | associated with | #2 |
longstanding HIV infection | neutral | stunting | children | - | associated with | #3 |
longstanding HIV infection | neutral | delayed puberty | children | - | associated with | #4 |
Vitamin D deficiency | decrease | bone health | children living with HIV in sub-Saharan Africa | - | has adverse impact on | #5 |
supplementation with vitamin D | neutral | bone mineral density | children living with HIV | - | aims to establish whether | #6 |
supplementation with vitamin D | neutral | bone mineral content | children living with HIV | - | aims to establish whether | #7 |
supplementation with vitamin D | neutral | bone turnover markers | children living with HIV | - | aims to establish whether | #8 |
supplementation with vitamin D | neutral | height | children living with HIV | - | aims to establish whether | #9 |
supplementation with vitamin D | neutral | pubertal development | children living with HIV | - | aims to establish whether | #10 |
weekly high-dose vitamin D | neutral | - | children living with HIV | - | trial of | #11 |
vitamin D supplementation | neutral | bone accrual | children | - | intervening to address deficits in | #12 |
vitamin D supplementation | increase | adolescent and early adult bone health | - | - | critical for optimising | #13 |
vitamin D supplementation | decrease | later adult osteoporotic fractures | - | - | prevention of | #14 |
BACKGROUND: Of the 2 million children living with HIV globally, 90% live in sub-Saharan Africa. Despite antiretroviral therapy, longstanding HIV infection is associated with several chronic complications in children including growth failure, particularly stunting and delayed puberty. Vitamin D deficiency, which is highly prevalent among children living with HIV in sub-Saharan Africa, has further adverse impact on bone health. This trial aims to establish whether supplementation with vitamin D METHODS/DESIGN: We will conduct an individually randomised, double-blinded, placebo-controlled trial of weekly high-dose vitamin D DISCUSSION: This is the largest trial to date of vitamin D supplementation in children living with HIV. Intervening to address deficits in bone accrual through childhood is critical for optimising adolescent and early adult bone health, and prevention of later adult osteoporotic fractures. Trial results will draw attention to the need to screen for and treat long-term comorbidities in children living with HIV in resource-limited settings. TRIAL REGISTRATION: Pan African Clinical Trials Registry PACTR20200989766029. Registered on September 3, 2020. URL of trial registry record: https://pactr.samrc.ac.za TRIAL STATUS: Participant follow-up completed; data analysis ongoing.