Whole tomato lipidic extract improved sperm quality in obese rats induced by a high-carbohydrate diet.
Study Goal
The researchers aimed to evaluate the effect of a whole tomato lipid extract on fertility and spermatogenesis in rats made obese through a high-carbohydrate diet.
Results Summary
The high-carbohydrate diet induced obesity, increased oxidative stress, and reduced sperm quality in rats. Treatment with tomato lipid extract improved sperm quality, reduced oxidative stress, and maintained testicular size in obese rats.
Population
Male Wistar rats (12 weeks old, n=114)
Effective Dosage
Not specified
Duration
3 months (high-carbohydrate diet induction) + treatment duration not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
high carbohydrate diet | increase | visceral and retroperitoneal adipose tissue | male Wistar rats | - | had a gain in | #1 |
high carbohydrate diet | increase | total cholesterol and triglyceride levels | male Wistar rats | - | an increase in | #2 |
high carbohydrate diet | increase | oxidative stress in the testis | male Wistar rats | - | increased | #3 |
high carbohydrate diet | neutral | testicular histology | male Wistar rats | - | lesions in | #4 |
high carbohydrate diet | decrease | testicular size | male Wistar rats | - | a reduction in | #5 |
high carbohydrate diet | decrease | sperm quality parameters (motility, viability, and concentration) | male Wistar rats | - | a reduction in | #6 |
whole tomato lipid extract | decrease | weight of gonadal adipose tissue | obese male Wistar rats | - | significantly decreased | #7 |
whole tomato lipid extract | decrease | oxidative stress | obese male Wistar rats | - | decreased | #8 |
whole tomato lipid extract | no change | testicular size | obese male Wistar rats | - | maintained | #9 |
whole tomato lipid extract | increase | sperm quality parameters | obese male Wistar rats | - | showed a significant increase in | #10 |
whole tomato lipid extract | neutral | histology of seminiferous tubules | obese male Wistar rats | - | improved | #11 |
BACKGROUND: Obesity represents a risk in the development of metabolic and oxidative stress (OS), as well as in male infertility. There is still no pharmacological treatment for obesity-induced male infertility, but the use of natural antioxidants has been proposed as a treatment. OBJECTIVE: The aim of this work is to evaluate the effect of a whole tomato lipid extract on rats that decreased their fertility and spermatogenesis after being induced obese with a high carbohydrate diet. MATERIALS AND METHODS: One hundred fourteen male Wistar rats of 12 weeks of age were used. Two groups were randomly formed non-obese control group (C, n = 54) and obese group (Ob, n = 54) that received 30% w/v sucrose solution for 3 months. Subsequently, the C and Ob group were divided into two groups: vehicle (C-Vh and Ob-Vh) that received corn oil as vehicle and tomato lipid extract (C-Ex and Ob-Ex) that received whole tomato lipid extract. The groups that received a hypercaloric diet had a gain in visceral and retroperitoneal adipose tissue, an increase in total cholesterol and triglyceride levels, increased OS in the testis, and lesions in testicular histology, as well as a reduction in testicular size and sperm quality parameters (motility, viability, and concentration). RESULTS: Treatment with whole tomato lipid extract significantly decreased the weight of gonadal adipose tissue and OS, maintained testicular size, showed a significant increase in sperm quality parameters and improved histology of seminiferous tubules. CONCLUSIONS: These results demonstrate a greater therapeutic and beneficial effect of the tomato lipid extract on sperm quality parameters in obese rats and therefore on fertility.