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Unlocking the health benefits of melatonin supplementation: A promising preventative and therapeutic strategy.

Medicine
January 1, 1970
Firas S Azzeh et al. (13 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to review melatonin's potential preventative and therapeutic effects on various diseases, including cancer, obesity, coronavirus, and cardiovascular diseases.

Results Summary

The abstract highlights melatonin's roles as an antioxidant, anti-cancer, anti-inflammatory, and immune-regulating agent, suggesting its potential in disease management, but calls for further research on long-term effects and molecular mechanisms.

Population

Not specified (general human application discussed)

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (5)
InterventionDirectionEndpointPopulationDosageImpactClaim #
Melatonin (MLT)
neutral
human sleep-wake patterns
human
-
is crucial in controlling
#1
Melatonin (MLT)
neutral
circadian rhythms
-
-
has long been recognized for regulating
#2
Melatonin (MLT)
neutral
various diseases
-
-
has demonstrated efficacy in managing
#3
Melatonin (MLT)
neutral
various diseases, including cancer, obesity, coronavirus, and cardiovascular diseases
-
-
brings about protective or therapeutic effects on
#4
Melatonin (MLT)
neutral
an antioxidant, anti-cancer, anti-inflammatory, and immune-regulating agent
-
-
functions as
#5
Abstract

Melatonin (MLT) is crucial in controlling human sleep-wake patterns. While it has long been recognized for regulating circadian rhythms, its demonstrated efficacy in managing various diseases has recently gained considerable attention. This review discusses MLT's potential preventative and therapeutic effects on various diseases. Several studies have focused on examining the molecular mechanisms through which MLT brings about its protective or therapeutic effects on various diseases, including cancer, obesity, coronavirus, and cardiovascular diseases. Numerous preventative and therapeutic applications of MLT have been proposed, resulting from its ability to function as an antioxidant, anti-cancer, anti-inflammatory, and immune-regulating agent. There is a need for further research to determine MLT's long-term effects on antioxidant defense systems, its preventative and therapeutic benefits, and its molecular basis.

Medical Subject Headings (MeSH)
MelatoninHumansNeoplasmsAntioxidantsDietary SupplementsCardiovascular DiseasesObesityAnti-Inflammatory AgentsCOVID-19Circadian Rhythm
Study Links
Quality Scores
SafetyNot Assessed
Efficacy75/10
Quality65/10
Citation Metrics
Total Citations2
Citations/Year2.0
Research Impact Scores
APT Score0.25
Weight Score1.31
Normalized Score0.63
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