Online Mindfulness-Based Intervention (eMBI) in management of dyspnea in patients with interstitial lung disease: A randomized clinical trial.
Study Goal
To evaluate the effect of an online Mindfulness-Based Intervention (eMBI) on reducing dyspnea in patients with interstitial lung diseases (ILDs).
Results Summary
The eMBI group showed a greater proportion of patients with reduced dyspnea compared to the control group (48.9% vs. 15.4%, p = 0.001), but no significant differences were observed in cough, quality of life, or psychological symptoms. No moderate or severe adverse events were reported.
Population
Patients ≥18 years with ILDs and a modified Medical Research Council (mMRC) dyspnea scale score of ≥1.
Effective Dosage
Not specified
Duration
8 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
online Mindfulness-Based Intervention (eMBI) | decrease | dyspnea according to the mMRC scale score | patients affected by different ILDs | 48.9 % versus 15.4 % | greater proportion of patients with a reduction | #1 |
online Mindfulness-Based Intervention (eMBI) | no change | Leicester Cough Questionnaire (LCQ) | patients affected by different ILDs | p = 0.666 | no significant difference | #2 |
online Mindfulness-Based Intervention (eMBI) | no change | King's Brief Interstitial Lung Disease (K-BILD) questionnaire | patients affected by different ILDs | p = 0.108 | no significant difference | #3 |
online Mindfulness-Based Intervention (eMBI) | no change | depression | patients affected by different ILDs | p = 0.08 | no significant difference | #4 |
online Mindfulness-Based Intervention (eMBI) | no change | anxiety | patients affected by different ILDs | p = 0.869 | no significant difference | #5 |
online Mindfulness-Based Intervention (eMBI) | no change | stress | patients affected by different ILDs | p = 0.789 | no significant difference | #6 |
online Mindfulness-Based Intervention (eMBI) | no change | adverse events | patients affected by different ILDs | - | no moderate or severe adverse events were observed | #7 |
RATIONALE: Dyspnea and cough are frequent symptoms in ILD patients. The management of these symptoms is challenging, and evidence-based therapies are lacking. OBJECTIVES: To evaluate the effect of an online Mindfulness-Based Intervention (eMBI) on reducing dyspnea in patients affected by different ILDs. METHODS: This study was a prospective, open-label, controlled trial that included patients ≥18 years and a modified Medical Research Council (mMRC) dyspnea scale score of ≥ 1. Patients were randomized into either the eMBI or the control group (CG) for 8 weeks. The primary outcome was the change in the dyspnea mMRC scale. The Leicester Cough Questionnaire (LCQ), King's Brief Interstitial Lung Disease (K-BILD) questionnaire, and Depression, Anxiety, and Stress Scale (DASS-21) were performed before and after the eight weeks. All analyses were conducted on an intention-to-treat basis. The study was registered at the Brazilian Registry of Clinical Trials (ReBEC), RBR-3s4mf9y. RESULTS: 24 patients in the eMBI and 25 in the CG completed the intervention. In the eMBI group, compared to the control group, there was a greater proportion of patients with a reduction in dyspnea according to the mMRC scale score (48.9 % versus, 15.4 %, p = 0.001). There was no significant difference between the groups in the LCQ (p = 0.666), or in the K-BILD (p = 0.108), depression (p = 0.08), or anxiety (p = 0.869 or stress (p = 0.789). No moderate or severe adverse events were observed in either group. CONCLUSIONS: Eight weeks eMBI is a potentially viable and safe approach, that can help manage dyspnea in ILD patients.