[LUMIDIAL: feasibility of light therapy in hemodialysis, pilot study and real-life experience].
Study Goal
The researchers aimed to determine whether light therapy improves sleep quality and reduces depressive symptoms in hemodialysis patients.
Results Summary
Light therapy showed no significant effect on sleep quality but demonstrated a trend toward reducing depression scores in hemodialysis patients. The technique was well tolerated and easy to implement.
Population
Hemodialysis patients with sleep and mood disorders.
Effective Dosage
30 minutes of light therapy three times a week.
Duration
Five weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
light therapy | no change | sleep quality (PSQI) | hemodialysis patients | p = 0.496 | had no significant effect | #1 |
light therapy | decrease | depression (DASS-21) | hemodialysis patients | -6.2 [95% CI, -12.5 to -0.05], p = 0.058 | trend towards a reduction | #2 |
light therapy | no change | sleep quality | hemodialysis patients | - | appears to have no effect | #3 |
light therapy | decrease | depressive states | hemodialysis patients | - | could reduce | #4 |
INTRODUCTION: Sleep and mood disorders are common in hemodialysis, but the effect of light therapy remains unknown in this population. METHODS: We conducted a randomized, controlled, open-label pilot trial comparing two group of either 30 minutes of light therapy three times a week, or no exposure. The primary endpoint was change in sleep quality (PSQI) after five weeks of light therapy, with change in mood (DASS-21) as a secondary endpoint. We added the description of the same criteria in a prospective, non-randomized, real-life post-trial cohort. STUDY RESULTS: We included 28 analyzable patients in the pilot study. Light therapy had no significant effect on PSQI reduction (p = 0.496). There was a trend towards a reduction in depression (-6.2 [95% CI, -12.5 to -0.05], p = 0.058). In the real-life cohort, out of 27 patients, 12 had a significant reduction in depression score (≥ 6 points). DISCUSSION: Light therapy performed in hemodialysis three times a week appears to have no effect on sleep quality, but could reduce depressive states. The technique is easy to implement, well tolerated and inexpensive. A multicenter randomized trial against the sham device will be needed to validate its effect on depression.